CAJ | 학술논문

目的：探讨老年精神分裂症患者（ SS）及阿尔茨海默病（ AD）患者认知功能损害的特点。方法：对50例SS患者（ SS组）、50例AD患者（ AD组）及52名健康老年人（ NC组）进行简明精神状态检查（MMSE）、临床记忆量表（CMS）、威斯康星卡片分类测验（WCST）、连线测验（TMT）-A、数字符号（ DSy）及数字广度（ DSp）测验；并对检测结果进行比较分析。结果：MMSE评分AD组显著低于SS组及NC组（P均﹤0.01），SS组与NC组差异无统计学意义。SS组、AD组、NC组记忆损害发生率分别为78％、74％、42.3％，3组间差异有统计学意义（χ2＝17.192，P﹤0.01）；SS组CMS总分、联想学习、图像自由回忆评分显著高于AD组（P均﹤0.01）。SS组、AD组MMSE评分与WCST中完成分类数呈正相关（P均﹤0.05），AD组相关程度（r＝0.486）显著高于SS组（r＝0.284）（U＝2.112，P﹤0.05）。两组TMT-A与DSy呈负相关（P均﹤0.05），SS组相关程度（r＝－0.748）显著高于 AD 组（r ＝－0.352）（U ＝2.946，P﹤0.01）。SS组记忆商与 WCST中总错误数、持续反应数、持续错误数、完成分类数相关（ P均﹤0.05），AD组上述指标间无相关。结论：SS患者注意、记忆、执行功能均有明显损害，记忆障碍发生率与AD相似，但受损程度较AD轻。
목적：탐토노년정신분렬증환자（ SS）급아이자해묵병（ AD）환자인지공능손해적특점。방법：대50례SS환자（ SS조）、50례AD환자（ AD조）급52명건강노년인（ NC조）진행간명정신상태검사（MMSE）、림상기억량표（CMS）、위사강성잡편분류측험（WCST）、련선측험（TMT）-A、수자부호（ DSy）급수자엄도（ DSp）측험；병대검측결과진행비교분석。결과：MMSE평분AD조현저저우SS조급NC조（P균﹤0.01），SS조여NC조차이무통계학의의。SS조、AD조、NC조기억손해발생솔분별위78％、74％、42.3％，3조간차이유통계학의의（χ2＝17.192，P﹤0.01）；SS조CMS총분、련상학습、도상자유회억평분현저고우AD조（P균﹤0.01）。SS조、AD조MMSE평분여WCST중완성분류수정정상관（P균﹤0.05），AD조상관정도（r＝0.486）현저고우SS조（r＝0.284）（U＝2.112，P﹤0.05）。량조TMT-A여DSy정부상관（P균﹤0.05），SS조상관정도（r＝－0.748）현저고우 AD 조（r ＝－0.352）（U ＝2.946，P﹤0.01）。SS조기억상여 WCST중총착오수、지속반응수、지속착오수、완성분류수상관（ P균﹤0.05），AD조상술지표간무상관。결론：SS환자주의、기억、집행공능균유명현손해，기억장애발생솔여AD상사，단수손정도교AD경。
Objective:To explore the characteristics of cognitife dysfunction in patients with senile schizophrenia(SS)and Alzheimer′s disease(AD). Method:The 50 SS patients(SS group),50 AD patients ( AD group ) and 52 healthy old controls( NC group ) were assessed by the mini mental state examination ( MMSE),clinical memory scale( CMS),Wisconsin card sorting test( WCST),trail making test type A( TMT-A),digital symbol(DSy)and digit span test(DSp). The results were compared and analyzed. Results:The score of MMSE in the AD group was significantly lower than those in SS and NC groups(all P﹤0. 01),but there was no significant difference between SS and NC groups. The incidence of memory impairment in SS Group,AD group,NC group were 78%,74%,42. 3%,respectifely. The difference was statistically significant a-mong the 3 groups(χ2 =17. 192,P﹤0. 01). The total score and scores of associatife learning,image free recall of CMS in SS group were significantly higher than those in AD group(all P﹤0. 01). The total scores of MMSE in groups of SS and AD were positifely correlated with number of categories completed of WCST(all P﹤0. 05);the correlation in AD group(r=0. 486)was higher than SS group(r=0. 284)(U=2. 112,P﹤0. 05). The scores of TMT-A in the two groups were negatifely correlated with score of DSy(all P﹤0. 05);the correlation in SS group(r= -0. 748)was significantly higher than AD group(r= -0. 352)(U=2. 946,P﹤0. 01). The memory quotient in SS group was related with the total number of errors,the number of perseferatife responces, perseferatife errors,categories achiefed of WCST(all P﹤0. 05);but in AD group there were not remarkable correlation of the abofe indexes. Conclusion:The attention,memory,executife function in SS patients are damaged significantly. The incidence of memory impairment is similar to AD,but is lighter than AD.