CAJ | 학술논문

目的：探讨单羧酸转运蛋白4(monocarboxylate transporters 4,MCT4)在子宫颈鳞状细胞癌组织中的表达及其临床病理学意义。方法采用免疫组化SP法分别检测72例子宫颈鳞状细胞癌组织和48例子宫颈正常组织中MCT4的表达,分析其表达与子宫颈鳞状细胞癌临床病理特征的关系。结果 MCT4在子宫颈鳞状细胞癌组织中的阳性率为81．9%(59/72),明显高于子宫颈正常组织(35．4%,17/48),两组相比差异有统计学意义(χ2=26．848,P<0．001)。 MCT4表达与子宫颈鳞状细胞癌临床分期(χ2=5．389,P=0．020)和淋巴结转移(χ2=4．706,P=0．030)有关,与患者年龄(χ2=1．238,P=0．266)、肿瘤分化程度(χ2=0．530,P=0．467)及浸润深度(χ2=1．300,P=0．254)无关。结论 MCT4在子宫颈鳞状细胞癌组织中高表达,且与临床分期和淋巴结转移密切相关,有望成为子宫颈鳞状细胞癌生物行为的有效指标之一。
목적：탐토단최산전운단백4(monocarboxylate transporters 4,MCT4)재자궁경린상세포암조직중적표체급기림상병이학의의。방법채용면역조화SP법분별검측72례자궁경린상세포암조직화48례자궁경정상조직중MCT4적표체,분석기표체여자궁경린상세포암림상병리특정적관계。결과 MCT4재자궁경린상세포암조직중적양성솔위81．9%(59/72),명현고우자궁경정상조직(35．4%,17/48),량조상비차이유통계학의의(χ2=26．848,P<0．001)。 MCT4표체여자궁경린상세포암림상분기(χ2=5．389,P=0．020)화림파결전이(χ2=4．706,P=0．030)유관,여환자년령(χ2=1．238,P=0．266)、종류분화정도(χ2=0．530,P=0．467)급침윤심도(χ2=1．300,P=0．254)무관。결론 MCT4재자궁경린상세포암조직중고표체,차여림상분기화림파결전이밀절상관,유망성위자궁경린상세포암생물행위적유효지표지일。
Purpose To explore the expression of monocarboxylate transporters 4 (MCT4) and its clinicopathologic significance in cer-vical squamous cell carcinoma. Methods The expression level of MCT4 in 72 cervical squamous cell carcinoma tissues and 48 cervi-cal normal tissues were detected by immunohistochemistry assay, and its relationship with clinical pathological features was analyzed. Results The positive rate of MCT4 was 81. 9% (59/72) in cervical squamous cell carcinoma tissues and 35. 4% (17/48) in normal cervical tissues. The positive rate of MCT4 in cervical squamous cell carcinoma was significantly higher than that in cervical normal tis-sues (χ2 =26. 848, P<0. 001). In addition, the expression of MCT4 protein was correlated with clinical stage (χ2 =5. 389, P=0. 020) and lymph node metastasis (χ2 =4. 706, P=0. 030). However, it did not correlated with age (χ2 =1. 238, P=0. 266), tumor differentiation (χ2 =0. 530, P=0. 467) or infiltration degree (χ2 =1. 300, P=0. 254) in patients with cervical squamous cell carcinoma. Conclusion The expression of MCT4 is up-regulated in cervical squamous cell carcinoma and correlate with clinical stage and lymph node metastasis of cervical squamous cell carcinoma. MCT4 may be a biomarker for evaluating the biological behavior of cer-vical squamous cell carcinoma.