CAJ | 학술논문

目的：观察头孢克洛缓释片递减方案治疗再发性尿路感染（RUTI）的效果及不良反应。方法将某院60例 RUTI 患者按来诊顺序分为治疗组和对照组，各30例，治疗组用头孢克洛缓释片递减方案治疗，对照组用左氧氟沙星片递减方案治疗，观察两组治疗方案临床疗效和不良反应情况。结果治疗组临床治愈24例（80．00％），对照组临床治愈16例（53．33％），治疗组临床治愈率高于对照组，与对照组比较差异有统计学意义（χ2＝4．80，P ＝0．028）。治疗组发生 RUTI 2例（6．67％），对照组发生 RUTI 8例（26．67％），治疗组再发率低于对照组，差异有统计学意义（χ2＝4．32，P ＝0．038）。治疗组不良反应发生率为16．67％，低于对照组的50．00％，差异有统计学意义（χ2＝7．50，P ＝0．006）。结论头孢克洛缓释片递减方案治疗 RUTI 疗效好、再发率低、不良反应少，可用于防止 RUTI 再发的治疗。
목적：관찰두포극락완석편체감방안치료재발성뇨로감염（RUTI）적효과급불량반응。방법장모원60례 RUTI 환자안래진순서분위치료조화대조조，각30례，치료조용두포극락완석편체감방안치료，대조조용좌양불사성편체감방안치료，관찰량조치료방안림상료효화불량반응정황。결과치료조림상치유24례（80．00％），대조조림상치유16례（53．33％），치료조림상치유솔고우대조조，여대조조비교차이유통계학의의（χ2＝4．80，P ＝0．028）。치료조발생 RUTI 2례（6．67％），대조조발생 RUTI 8례（26．67％），치료조재발솔저우대조조，차이유통계학의의（χ2＝4．32，P ＝0．038）。치료조불량반응발생솔위16．67％，저우대조조적50．00％，차이유통계학의의（χ2＝7．50，P ＝0．006）。결론두포극락완석편체감방안치료 RUTI 료효호、재발솔저、불량반응소，가용우방지 RUTI 재발적치료。
Objective To explore the efficacy and adverse reactions of diminishing scheme of cefaclor sustained re-lease tablets in the treatment of recurrent urinary tract infection(RUTI).Methods 60 RUTI patients in a hospital were divided into treatment group(n=30)and control group (n=30),patients in treatment group were treated with diminishing scheme of cefaclor sustained release tablets,patients in control group were treated with diminishing scheme of levofloxacin tablets,clinical therapeutic efficacy and adverse reactions of two groups were observed. Results The curative rate in treatment group was higher than control group ([80.00%,n =24]vs [53.33%,n =16])(χ2 =4.80,P =0.028).The incidence of RUTI in treatment group was lower than control group ([6.67%,n=2]vs [26.67%,n=8])(χ2 =4.32,P =0.038).Incidence of adverse reactions in treatment group was lower than control group (16.67% vs 50.00%)(χ2 =7.50,P =0.006).Conclusion The diminishing scheme of cefaclor sus-tained release tablets in the treatment of RUTI has good curative efficacy,low recurrence rate,fewer adverse reac-tions,and can be used for the treatment of recurrence of RUTI.