中外医疗
中外醫療
중외의료
CHINA FOREIGN MEDICAL TREATMENT
2014年
35期
14-15
,共2页
急性白血病%C反应蛋白%D-二聚体
急性白血病%C反應蛋白%D-二聚體
급성백혈병%C반응단백%D-이취체
Acute leukemia%C-reactive protein%D-dimer
目的:探讨C反应蛋白和D-二聚体对急性白血病伴感染患者的临床检查价值。方法选取该院血液科2011年1月—2013年12月诊断为急性白血病的住院病人,诊断为有感染的患者定义为感染组40例;诊断为弥漫性血管内凝血的患者为弥漫性血管内凝血组40例;同时有感染与弥漫性血管内凝血的患者归为感染+弥漫性血管内凝血组40例。测取各组C反应蛋白和D-二聚体数值。结果感染组、弥漫性血管内凝血组及感染+弥漫性血管内凝血组C反应蛋白和D-二聚体分别为[(42.8依10.5)mg/L、(0.8依0.3)μg/L;(16.5依5.8)mg/L、(1.5依0.6)μg/L;(88.7依21.7)mg/L、(6.8依1.7)μg/L],C反应蛋白和D-二聚体以联合组最高,弥漫性血管内凝血组最低,三组的差异有统计学意义(P<0.05);以C反应蛋白[(<10 mg/L)、(10≤,<100 mg/L)、(≥100 mg/L)]进行分层,CRP≥100 mg/L的人群中,发生DIC比例及血中D-二聚体值最高,而C反应蛋白<10 mg/L的人群中,发生DIC比例及血中D-二聚体值最低,差异有统计学意义(P<0.05)。结论该研究认为急性白血病病人普遍存在感染和异常凝血,可以C反应蛋白和D-二聚体作为检测指标,判断患者是否有发生弥漫性血管内凝血与感染的风险。
目的:探討C反應蛋白和D-二聚體對急性白血病伴感染患者的臨床檢查價值。方法選取該院血液科2011年1月—2013年12月診斷為急性白血病的住院病人,診斷為有感染的患者定義為感染組40例;診斷為瀰漫性血管內凝血的患者為瀰漫性血管內凝血組40例;同時有感染與瀰漫性血管內凝血的患者歸為感染+瀰漫性血管內凝血組40例。測取各組C反應蛋白和D-二聚體數值。結果感染組、瀰漫性血管內凝血組及感染+瀰漫性血管內凝血組C反應蛋白和D-二聚體分彆為[(42.8依10.5)mg/L、(0.8依0.3)μg/L;(16.5依5.8)mg/L、(1.5依0.6)μg/L;(88.7依21.7)mg/L、(6.8依1.7)μg/L],C反應蛋白和D-二聚體以聯閤組最高,瀰漫性血管內凝血組最低,三組的差異有統計學意義(P<0.05);以C反應蛋白[(<10 mg/L)、(10≤,<100 mg/L)、(≥100 mg/L)]進行分層,CRP≥100 mg/L的人群中,髮生DIC比例及血中D-二聚體值最高,而C反應蛋白<10 mg/L的人群中,髮生DIC比例及血中D-二聚體值最低,差異有統計學意義(P<0.05)。結論該研究認為急性白血病病人普遍存在感染和異常凝血,可以C反應蛋白和D-二聚體作為檢測指標,判斷患者是否有髮生瀰漫性血管內凝血與感染的風險。
목적:탐토C반응단백화D-이취체대급성백혈병반감염환자적림상검사개치。방법선취해원혈액과2011년1월—2013년12월진단위급성백혈병적주원병인,진단위유감염적환자정의위감염조40례;진단위미만성혈관내응혈적환자위미만성혈관내응혈조40례;동시유감염여미만성혈관내응혈적환자귀위감염+미만성혈관내응혈조40례。측취각조C반응단백화D-이취체수치。결과감염조、미만성혈관내응혈조급감염+미만성혈관내응혈조C반응단백화D-이취체분별위[(42.8의10.5)mg/L、(0.8의0.3)μg/L;(16.5의5.8)mg/L、(1.5의0.6)μg/L;(88.7의21.7)mg/L、(6.8의1.7)μg/L],C반응단백화D-이취체이연합조최고,미만성혈관내응혈조최저,삼조적차이유통계학의의(P<0.05);이C반응단백[(<10 mg/L)、(10≤,<100 mg/L)、(≥100 mg/L)]진행분층,CRP≥100 mg/L적인군중,발생DIC비례급혈중D-이취체치최고,이C반응단백<10 mg/L적인군중,발생DIC비례급혈중D-이취체치최저,차이유통계학의의(P<0.05)。결론해연구인위급성백혈병병인보편존재감염화이상응혈,가이C반응단백화D-이취체작위검측지표,판단환자시부유발생미만성혈관내응혈여감염적풍험。
Objective To evaluate the value of clinical examination of C-reactive protein and D-dimer in acute leukemia patients with infection. Methods The inpatients diagnosed with acute leukemia in the Department of Hematology of our hospital were se-lected. Those acute leukemia patients complicated by infection were set as the infection group(40 cases), those complicated by dis-seminated intravascular coagulation(DIC) were set as the disseminated intravascular coagulation group(40 cases), and those compli-cated by infection and DIC were set as the infection and disseminated intravascular coagulation group(40 cases). And the values of C-reactive protein and D-dimer of the groups were measured. Results The value of C-reactive protein of the infection group, dis-seminated intravascular coagulation group, and the infection and disseminated intravascular coagulation group was (42.8±10.5)mg/L, (16.5±5.8)mg/L,(88.7±21.7)mg/L, respectively, and the value of D-dimer of the three groups was (0.8±0.3)μg/L,(1.5±0.6)μg/L, (6.8±1.7)μg/L, respectively, the value of C-reactive protein and D-dimer of the infection and disseminated intravascular coagula-tion group were the highest, and those of the disseminated intravascular coagulation group were the lowest, the differences between the three groups were statistically significant (P<0.05). By the C-reactive protein (CRP) value, the patients were stratified into pa-tients with CRP value <10 mg/L, patients with CRP value ≥10mg/L but <100mg/L and patients with CRP value ≥100mg/L. The incidence of DIC and the value of D-dimer in blood were the highest in the patients with CRP value ≥100mg/L, while those were the lowest in the patients with CRP value <10mg/L, the differences were statistically significant (P<0.05). Conclusion We believe that patients with acute leukemia have infection and abnormal blood coagulation generally, so C-reactive protein and D-dimer can be set as the detection indicators to judge whether the patients have disseminated intravascular coagulation and infection.