中国医药导刊
中國醫藥導刊
중국의약도간
CHINESE JOURNAL OF MEDICAL GUIDE
2015年
1期
96-98
,共3页
COX-2%PCNA%乳腺癌%生血汤%新辅助化疗
COX-2%PCNA%乳腺癌%生血湯%新輔助化療
COX-2%PCNA%유선암%생혈탕%신보조화료
Cox-2%PCNA%Breast cancer%Shengxue decoction%Neoadjuvant chemotherapy
目的：探讨COX-2、PCNA表达与乳腺癌术后生血汤联合新辅助化疗疗效的关系。方法：选取我院乳腺癌术后患者122例，全部患者术中采集乳腺癌组织标本，采用免疫组化方法检测COX-2、PCNA表达，且所有患者均给予术后生血汤联合新辅助化疗，根据不同的治疗效果将患者分为有效组和无效组，比较两组COX-2、PCNA阳性表达率。结果：治疗有效率为60.66%，COX-2阳性率为55.74%， PCNA阳性率为73.77%，其中有效组COX-2、PCNA阳性表达率显著低于无效组（P＜0.05），COX-2（＋）/PCNA（＋）组完全缓解率和治疗有效率均明显低于COX-2（－）/PCNA（－）组，比较差异具有显著性（P＜0.05）。经Pearson相关性分析发现，COX-2与PCNA表达呈正相关（r=0.512，P＜0.05）。结论：乳腺癌术后生血汤与新辅助化疗联合治疗有效者COX-2、PCNA阳性表达率显著降低，且COX-2、PCNA阳性表达疗效亦显著降低，COX-2、PCNA表达与疾病疗效关系密切。
目的：探討COX-2、PCNA錶達與乳腺癌術後生血湯聯閤新輔助化療療效的關繫。方法：選取我院乳腺癌術後患者122例，全部患者術中採集乳腺癌組織標本，採用免疫組化方法檢測COX-2、PCNA錶達，且所有患者均給予術後生血湯聯閤新輔助化療，根據不同的治療效果將患者分為有效組和無效組，比較兩組COX-2、PCNA暘性錶達率。結果：治療有效率為60.66%，COX-2暘性率為55.74%， PCNA暘性率為73.77%，其中有效組COX-2、PCNA暘性錶達率顯著低于無效組（P＜0.05），COX-2（＋）/PCNA（＋）組完全緩解率和治療有效率均明顯低于COX-2（－）/PCNA（－）組，比較差異具有顯著性（P＜0.05）。經Pearson相關性分析髮現，COX-2與PCNA錶達呈正相關（r=0.512，P＜0.05）。結論：乳腺癌術後生血湯與新輔助化療聯閤治療有效者COX-2、PCNA暘性錶達率顯著降低，且COX-2、PCNA暘性錶達療效亦顯著降低，COX-2、PCNA錶達與疾病療效關繫密切。
목적：탐토COX-2、PCNA표체여유선암술후생혈탕연합신보조화료료효적관계。방법：선취아원유선암술후환자122례，전부환자술중채집유선암조직표본，채용면역조화방법검측COX-2、PCNA표체，차소유환자균급여술후생혈탕연합신보조화료，근거불동적치료효과장환자분위유효조화무효조，비교량조COX-2、PCNA양성표체솔。결과：치료유효솔위60.66%，COX-2양성솔위55.74%， PCNA양성솔위73.77%，기중유효조COX-2、PCNA양성표체솔현저저우무효조（P＜0.05），COX-2（＋）/PCNA（＋）조완전완해솔화치료유효솔균명현저우COX-2（－）/PCNA（－）조，비교차이구유현저성（P＜0.05）。경Pearson상관성분석발현，COX-2여PCNA표체정정상관（r=0.512，P＜0.05）。결론：유선암술후생혈탕여신보조화료연합치료유효자COX-2、PCNA양성표체솔현저강저，차COX-2、PCNA양성표체료효역현저강저，COX-2、PCNA표체여질병료효관계밀절。
Objective: To study the relationship between Cox-2 and PCNA express and efficacy of postoperative Shengxue decoction combined neoadjuvant chemotherapy for breast cancer.Methods:122 cases of postoperative breast cancer patients from our hospital were selection, breast cancer tissue were collected during operation, cox-2, PCNA express were detected by immunohistochemical method, and all were given Shengxue decoction combined neoadjuvant chemotherapy, according different effect were divided into effective and ineffective group, cox-2, PCNA positive expression rate were compared.Results:The effective rate was 60.66%, cox-2 positive expression rate was 55.74%, PCNA positive expression rate was 73.77%, cox-2, PCNA positive expression rate of effective group was significantly lower than ineffective group(P<0.05), complete remission and effective rate of cox-2 (+)/PCNA (+) group were significantly lower than cox-2 (-)/PCNA (-) group, compared with significant difference (P<0.05). The Pearson correlation analysis found, cox-2 and PCNA expression were positively correlated (r=0.512,P<0.05).Conclusion:Cox-2, PCNA positive expression in effective treating breast cancer patients of postoperative Shengxue decoction and neoadjuvant chemotherapy combination therapy are significantly reduced, and the curative effect of both positive expression is significantly reduced, cox-2, PCNA express are closely related to disease curative effect.
