中国医药导刊
中國醫藥導刊
중국의약도간
CHINESE JOURNAL OF MEDICAL GUIDE
2015年
1期
89-90,93
,共3页
马洪波%路群%董燕娇%周忠民
馬洪波%路群%董燕嬌%週忠民
마홍파%로군%동연교%주충민
烧伤%急性肾损伤%白细胞介素18%肾损伤分子-1
燒傷%急性腎損傷%白細胞介素18%腎損傷分子-1
소상%급성신손상%백세포개소18%신손상분자-1
Burn%Acute kidney injury%Interleukin-18%Kidney injury molecule-1
目的：探讨白细胞介素-18（IL-18）及尿肾损伤分子-1（KIM-1）水平在不同程度烧伤患者合并急性肾损伤（AKI）早期诊断中的临床意义。方法：选择2011年1至2014年1月收治的80例住院烧伤患者，按烧伤面积和深度分轻、中及重度烧伤组，体检者为对照组。分别留取血液及尿液，检测血全项水平；ELISA法检测和分析尿KIM-1及IL-18水平与烧伤程度等。结果：（1）轻、中、重度组及对照组的尿KIM-1水平均明显高于对照组（P＜0.05）；而三组患者及对照组的尿IL-18水平比较差异无统计学意义。（2）重度烧伤合并AKI患者尿KIM-1及IL-18水平明显高于重度烧伤不合并AKI患者，差异均有统计学意义（P＜0.05），且尿KIM-1及IL-18升高早于血肌酐升高。（3）尿KIM-1与血清BUN、Scr呈正相关，但与ALB呈负相关（P均＜0.05）。尿IL-18与血清Cr低度相关，但与血清BUN、ALB无相关性。结论：尿IL-18、KIM-1可以作为预测不同程度烧伤患者合并AKI的早期敏感指标，为烧伤患者早期预防AKI提供一定的临床线索。
目的：探討白細胞介素-18（IL-18）及尿腎損傷分子-1（KIM-1）水平在不同程度燒傷患者閤併急性腎損傷（AKI）早期診斷中的臨床意義。方法：選擇2011年1至2014年1月收治的80例住院燒傷患者，按燒傷麵積和深度分輕、中及重度燒傷組，體檢者為對照組。分彆留取血液及尿液，檢測血全項水平；ELISA法檢測和分析尿KIM-1及IL-18水平與燒傷程度等。結果：（1）輕、中、重度組及對照組的尿KIM-1水平均明顯高于對照組（P＜0.05）；而三組患者及對照組的尿IL-18水平比較差異無統計學意義。（2）重度燒傷閤併AKI患者尿KIM-1及IL-18水平明顯高于重度燒傷不閤併AKI患者，差異均有統計學意義（P＜0.05），且尿KIM-1及IL-18升高早于血肌酐升高。（3）尿KIM-1與血清BUN、Scr呈正相關，但與ALB呈負相關（P均＜0.05）。尿IL-18與血清Cr低度相關，但與血清BUN、ALB無相關性。結論：尿IL-18、KIM-1可以作為預測不同程度燒傷患者閤併AKI的早期敏感指標，為燒傷患者早期預防AKI提供一定的臨床線索。
목적：탐토백세포개소-18（IL-18）급뇨신손상분자-1（KIM-1）수평재불동정도소상환자합병급성신손상（AKI）조기진단중적림상의의。방법：선택2011년1지2014년1월수치적80례주원소상환자，안소상면적화심도분경、중급중도소상조，체검자위대조조。분별류취혈액급뇨액，검측혈전항수평；ELISA법검측화분석뇨KIM-1급IL-18수평여소상정도등。결과：（1）경、중、중도조급대조조적뇨KIM-1수평균명현고우대조조（P＜0.05）；이삼조환자급대조조적뇨IL-18수평비교차이무통계학의의。（2）중도소상합병AKI환자뇨KIM-1급IL-18수평명현고우중도소상불합병AKI환자，차이균유통계학의의（P＜0.05），차뇨KIM-1급IL-18승고조우혈기항승고。（3）뇨KIM-1여혈청BUN、Scr정정상관，단여ALB정부상관（P균＜0.05）。뇨IL-18여혈청Cr저도상관，단여혈청BUN、ALB무상관성。결론：뇨IL-18、KIM-1가이작위예측불동정도소상환자합병AKI적조기민감지표，위소상환자조기예방AKI제공일정적림상선색。
Objective: To investigate interleukin -18 (IL-18) and urinary kidney injury molecule -1 (KIM-1) levels in patients with varying degrees of burn patients with acute kidney injury (AKI) The clinical significance of early diagnosis.Methods:80 cases of hospitalized burn patients in our hospital from January 2011 to January 2014, Press the burn area and depth of mild, moderate and severe burn group,volunteers as a control group. Blood and urine specimens were detected in blood levels of full term; ELISA assay and analysis of urinary KIM-1 and IL-18 levels and the degree burns.Results:(1)mild, moderate, severe and control groups urinary KIM-1 levels were significantly higher (P<0.05); and urine IL-18 level difference between the three groups of patients and the control group was not statistically significance.(2)severe burns merger urinary KIM-1 and IL-18 levels were significantly higher AKI severe burn patients without AKI merger,the differences were statistically significant (P<0.05), and urinary KIM-1 and IL-18 increased early in elevated serum creatinine.(3)urinary KIM-1 was positively correlated with serum BUN, Scr was, but with ALB was negatively correlated (P<0.05).Urine and serum IL-18 Cr low correlation, but with serum BUN, ALB no correlation.Conclusion:Urinary IL-18, KIM-1 can be used as predictive AKI patients with varying degrees of burns sensitive early indicator for burn prevention in patients with early clinical AKI provide some clues.
