CAJ | 학술논문

目的：探究静脉补铁对维持性血液透析患者贫血的临床疗效。方法：于2011年12月～2013年12月在我院行维持性血液透析伴有贫血的患者64例随机分成两组各32例，静脉补蔗糖铁为研究组，速力菲口服为对照组，分析两组疗效、治疗前后的相关血液和铁指标以及不良反应。结果：研究组比对照组又更高的治疗有效率（93.75% VS 34.38%，P＜0.05）；且研究组8周、12周的Hb、Hct和网织红细胞的数量，及血清铁、转铁蛋白的饱和度及血清的铁蛋白指标，比对照组改善显著，有统计学上的意义（P＜0.05）。结论：维持性血液透析伴贫血者，口服铁剂不耐受时可予静脉蔗糖铁，能有效纠正维持性血液透析患者的铁缺乏症状。
목적：탐구정맥보철대유지성혈액투석환자빈혈적림상료효。방법：우2011년12월～2013년12월재아원행유지성혈액투석반유빈혈적환자64례수궤분성량조각32례，정맥보자당철위연구조，속력비구복위대조조，분석량조료효、치료전후적상관혈액화철지표이급불량반응。결과：연구조비대조조우경고적치료유효솔（93.75% VS 34.38%，P＜0.05）；차연구조8주、12주적Hb、Hct화망직홍세포적수량，급혈청철、전철단백적포화도급혈청적철단백지표，비대조조개선현저，유통계학상적의의（P＜0.05）。결론：유지성혈액투석반빈혈자，구복철제불내수시가여정맥자당철，능유효규정유지성혈액투석환자적철결핍증상。
Objective: To explore the efficacy of Intravenous iron supplementation in improving anemia in patients undergoing maintenance hemodialysis (MHD).Methods:Sixty-four HD patients with anemia treated in our hospital between December, 2011 and December, 2013 were randomly assigned to the study group with intravenous iron supplementation (n=32), or the control group with oral iron supplementation (n=32).Hemoglobin( HGB), hematocrit (Hct), reticulocyte (Ret), serum iron (Fe), transferrin saturation (TSAT), and ferritin level were periodically measured over 12 consecutive treatment weeks to assess the efficacy.Results:The effectiveness in the study group was better than that in the control group (93.75% Vs 34.38%,P<0.05). Additionally, there were significantly higher levels of HGB, Hct, Ret, Fe, TSAT, and Ferritin in the study group than those in the control group at week 8, 12 after the initiation of study (P<0.05). Conclusion:Intravenous iron supplementation can effectively improve iron insufficiency, may thus be use correction of anemia in MHD patients with oral iron intolerance.