CAJ | 학술논문

目的：探讨复方甘草酸苷预防结核药物性肝炎序贯治疗的临床效果°方法选取2011年8月—2014年2月期间在该中心诊治的结核药物性肝炎患者140例，根据随机抽签法分为治疗组与对照组各70例，对照组给予常规治疗，在此基础上治疗组加用复方甘草酸苷预防序贯治疗，都治疗3个月°结果治疗后治疗组与对照组的有效率分别为97.1%和84.3%，治疗组总有效率明显高于对照组(P<0.05)°两组治疗后血清ALT与AST值明显下降，与治疗前对比差异有统计学意义(P<0.05)，同时治疗后治疗组的血清ALT与AST值明显低于对照组(P<0.05)°结论复方甘草酸苷预防结核药物性肝炎序贯治疗能有效发挥肝功能的保护作用，提高预后疗效，值得推广应用°
목적：탐토복방감초산감예방결핵약물성간염서관치료적림상효과°방법선취2011년8월—2014년2월기간재해중심진치적결핵약물성간염환자140례，근거수궤추첨법분위치료조여대조조각70례，대조조급여상규치료，재차기출상치료조가용복방감초산감예방서관치료，도치료3개월°결과치료후치료조여대조조적유효솔분별위97.1%화84.3%，치료조총유효솔명현고우대조조(P<0.05)°량조치료후혈청ALT여AST치명현하강，여치료전대비차이유통계학의의(P<0.05)，동시치료후치료조적혈청ALT여AST치명현저우대조조(P<0.05)°결론복방감초산감예방결핵약물성간염서관치료능유효발휘간공능적보호작용，제고예후료효，치득추엄응용°
Objective To investigate the clinical effect of compound glycyrrhizin in the sequentially preventive treatment of antitu_berculosis drug-induced hepatitis. Methods 140 cases with antituberculosis drug-induced hepatitis diagnosed and treated in our center from August 2011 to February 2014 were selected and randomly divided into the treatment group and the control group with 70 cases in each. The control group were given the conventional treatment, and the treatment group were given compound gly_cyrrhizin sequentially preventive treatment based on the treatment given to the control group. Both groups were treated for 3 months. Results After treatment, the effective rate of the treatment group and the control group was 97.1%, 84.3%, respectively, the total efficiency of the treatment group was significantly higher (P<0.05). After treatment, the serum ALT and AST values of both groups decreased significantly compared with those before treatment with significant difference (P<0.05), and the serum ALT and AST values of the treatment group were significantly lower than those of the control group(P<0.05). Conclusion Compound gly_cyrrhizin in the sequentially preventive treatment of antituberculosis drug-induced hepatitis can effectively protect the liver func_tion and improve the prognosis, which should be widely applied.