CAJ | 학술논문

目的：探讨非小细胞肺癌(NSCLC)表皮生长因子受体(EGFR)基因突变情况及其与临床病理的关系。方法对2010年1月-2014年1月来该院诊治的159份非小细胞肺癌手术切除标本进行分析,实验中采用基因测序方法对标本中的EGFR基因突变情况进行检测,分析其与临床病理的关系。结果159例样本中,EGFR基因突变检出率12.6%(20/159),突变主要集中在19号外显子的缺失和21号外显子的点突变。女性患者基因突变检出率明显高于男性患者(P﹤0.01)。腺癌及细支气管肺泡癌患者基因突变检出率明显高于其他组织学分型(P﹤0.01)。高分化患者基因突变检出率高于中-低分化检出率(P<0.05)。 EGFR基因突变与年龄及淋巴结转移与否无关(P>0.05)。结论非小细胞肺癌患者EGFR基因突变与性别﹑组织学分型及分化程度密切相关。
목적：탐토비소세포폐암(NSCLC)표피생장인자수체(EGFR)기인돌변정황급기여림상병리적관계。방법대2010년1월-2014년1월래해원진치적159빈비소세포폐암수술절제표본진행분석,실험중채용기인측서방법대표본중적EGFR기인돌변정황진행검측,분석기여림상병리적관계。결과159례양본중,EGFR기인돌변검출솔12.6%(20/159),돌변주요집중재19호외현자적결실화21호외현자적점돌변。녀성환자기인돌변검출솔명현고우남성환자(P﹤0.01)。선암급세지기관폐포암환자기인돌변검출솔명현고우기타조직학분형(P﹤0.01)。고분화환자기인돌변검출솔고우중-저분화검출솔(P<0.05)。 EGFR기인돌변여년령급림파결전이여부무관(P>0.05)。결론비소세포폐암환자EGFR기인돌변여성별﹑조직학분형급분화정도밀절상관。
Objective To investigate the non-small cell lung cancer (NSCLC) epidermal growth factor receptor (EGFR) gene muta-tion and its relationship with clinical pathology. Methods 159 patients with NSCLC were diagnosed and treated in our hospital from January 2010 to January 2014. And the surgical resection specimens of them were analyzed. Gene sequencing method was used to detect the EGFR gene mutation in the specimens, and the relationship between the EGFR gene mutation and clinical pathology was analyzed. Results In 159 samples, the EGFR gene mutation detection rate was 12.6% (20/159). The gene mutations mainly were the deletion in exon 19 and exon 21 point mutation. The gene mutation detection rate of the female patients was sig-nificantly higher than that of the male patients (P<0.01). The gene mutation detection rates of adenocarcinoma and bronchioloalve-olar carcinoma were significantly higher than those of other histological types (P<0.01). The gene mutation detection rate of patients with high differentiation was higher than that of those with medium or low differentiation (P<0.05). EGFR gene mutation had noth-ing to do with age, and the metastasis of lymph node (P>0.05). Conclusion EGFR mutation in patients with non-small cell lung cancer is closely related with the sex, histological type and differentiation degree.