中国继续医学教育
中國繼續醫學教育
중국계속의학교육
CHINA CONTINUING MEDICAL EDUCATION
2015年
3期
38-39
,共2页
宫颈癌%ki-67%凋亡%新辅助化疗
宮頸癌%ki-67%凋亡%新輔助化療
궁경암%ki-67%조망%신보조화료
Cervical carcinoma%ki-67%Apoptosis%Neoadjuvant chemotherapy
目的：观察新辅助化疗对宫颈癌细胞增殖和凋亡的影响。方法采用免疫组织化学S-P法检测30名宫颈癌患者化疗前后癌组织中ki-67表达阳性率的差异；用TUNEL法检测化疗前后癌组织中细胞凋亡阳性率的差异。结果化疗临床有效率为63.3%；化疗后癌组织中ki-67的表达由70%降至36.7%，差异显著，而凋亡阳性率由30%升至66.7%，差异显著；化疗后临床有效者凋亡阳性率表达高于无效者，差异显著。结论新辅助化疗能显著抑制肿瘤细胞增殖、诱导凋亡；ki-67表达的下调及凋亡上调可能是新辅助化疗抗癌作用的重要机制之一。
目的：觀察新輔助化療對宮頸癌細胞增殖和凋亡的影響。方法採用免疫組織化學S-P法檢測30名宮頸癌患者化療前後癌組織中ki-67錶達暘性率的差異；用TUNEL法檢測化療前後癌組織中細胞凋亡暘性率的差異。結果化療臨床有效率為63.3%；化療後癌組織中ki-67的錶達由70%降至36.7%，差異顯著，而凋亡暘性率由30%升至66.7%，差異顯著；化療後臨床有效者凋亡暘性率錶達高于無效者，差異顯著。結論新輔助化療能顯著抑製腫瘤細胞增殖、誘導凋亡；ki-67錶達的下調及凋亡上調可能是新輔助化療抗癌作用的重要機製之一。
목적：관찰신보조화료대궁경암세포증식화조망적영향。방법채용면역조직화학S-P법검측30명궁경암환자화료전후암조직중ki-67표체양성솔적차이；용TUNEL법검측화료전후암조직중세포조망양성솔적차이。결과화료림상유효솔위63.3%；화료후암조직중ki-67적표체유70%강지36.7%，차이현저，이조망양성솔유30%승지66.7%，차이현저；화료후림상유효자조망양성솔표체고우무효자，차이현저。결론신보조화료능현저억제종류세포증식、유도조망；ki-67표체적하조급조망상조가능시신보조화료항암작용적중요궤제지일。
Objective To determine the effect of neoadjuvant chemotherapy (NACT) for cervix cancer on cell proliferation and apoptosis.Methods The specimens from 30 cases of cervical carcinoma before and after neoadjuvant chemotherapy were detected, the diversity of positive expression rates of ki-67 by S-P immunohistochemical method and the diversity of apoptosis positivity by TUNEL method.Result Clinical response was 63.3%, before and after NACT, the expression of ki-67 were 70% and 36.7% respectively and apoptosis positivity were 30% and 66.7%. Significant difference of ki-67 and apoptosis could be observed before and after NACT. The apoptosis positivity after NACT was signiifcantly higher in effective case.Conclusion NACT can inhibit proliferation and induce apoptosis of cells in cervical carcinoma. The change of ki-67 and apoptosis expression may be of molecule mechanisms leading to anti-tumor function of NACT.
