中国中医眼科杂志
中國中醫眼科雜誌
중국중의안과잡지
JOURNAL OF TRADITIONAL CHINESE OPHTHALMOLOGY
2014年
6期
423-425
,共3页
真菌性%角膜溃疡%龙胆泻肝汤%结膜瓣遮盖术
真菌性%角膜潰瘍%龍膽瀉肝湯%結膜瓣遮蓋術
진균성%각막궤양%룡담사간탕%결막판차개술
fungal%corneal ulcer%Longdan Xiegan Decoction%conjunctival flap covering surgery
目的：探讨龙胆泻肝汤加减方联合结膜瓣遮盖治疗真菌性角膜溃疡的临床效果。方法84例（84只眼）真菌性角膜溃疡的患者随机分成2组。对照组行常规药物治疗及结膜瓣遮盖联合术，中药治疗组在对照组的基础上添加口服龙胆泻肝汤加减方（免煎剂）。观察2组患者患眼的症状改善、溃疡愈合及视力情况。结果治疗后2组患者的角膜刺激症状和视力有一定程度改善。中药治疗组46例中，治愈36例，好转8例，无效2例，治愈率78.26%，总有效率95.65%；对照组38例中，治愈21例，好转10例，无效7例，治愈率55.26%，总有效率81.58%；2组差异有统计学意义（Mann-Whitney U检验，Z=-2.393，P=0.017）。随访12～18个月，中药治疗组治愈患者未见复发，对照组治愈患者复发2例。结论在常规药物联合结膜瓣覆盖的基础上增加龙胆泻肝汤加减方治疗，可以提高对真菌性角膜溃疡的治疗效果。
目的：探討龍膽瀉肝湯加減方聯閤結膜瓣遮蓋治療真菌性角膜潰瘍的臨床效果。方法84例（84隻眼）真菌性角膜潰瘍的患者隨機分成2組。對照組行常規藥物治療及結膜瓣遮蓋聯閤術，中藥治療組在對照組的基礎上添加口服龍膽瀉肝湯加減方（免煎劑）。觀察2組患者患眼的癥狀改善、潰瘍愈閤及視力情況。結果治療後2組患者的角膜刺激癥狀和視力有一定程度改善。中藥治療組46例中，治愈36例，好轉8例，無效2例，治愈率78.26%，總有效率95.65%；對照組38例中，治愈21例，好轉10例，無效7例，治愈率55.26%，總有效率81.58%；2組差異有統計學意義（Mann-Whitney U檢驗，Z=-2.393，P=0.017）。隨訪12～18箇月，中藥治療組治愈患者未見複髮，對照組治愈患者複髮2例。結論在常規藥物聯閤結膜瓣覆蓋的基礎上增加龍膽瀉肝湯加減方治療，可以提高對真菌性角膜潰瘍的治療效果。
목적：탐토룡담사간탕가감방연합결막판차개치료진균성각막궤양적림상효과。방법84례（84지안）진균성각막궤양적환자수궤분성2조。대조조행상규약물치료급결막판차개연합술，중약치료조재대조조적기출상첨가구복룡담사간탕가감방（면전제）。관찰2조환자환안적증상개선、궤양유합급시력정황。결과치료후2조환자적각막자격증상화시력유일정정도개선。중약치료조46례중，치유36례，호전8례，무효2례，치유솔78.26%，총유효솔95.65%；대조조38례중，치유21례，호전10례，무효7례，치유솔55.26%，총유효솔81.58%；2조차이유통계학의의（Mann-Whitney U검험，Z=-2.393，P=0.017）。수방12～18개월，중약치료조치유환자미견복발，대조조치유환자복발2례。결론재상규약물연합결막판복개적기출상증가룡담사간탕가감방치료，가이제고대진균성각막궤양적치료효과。
OBJECTIVE To investigate the clinical effect of Longdan Xiegan decoction combined with con-junctival flap covering in the treatment of fungal corneal ulcer. METHODS Eighty-four cases (84 eyes) of fungal corneal ulcer were randomly divided into 2 groups. The control group received conventional drug treatment and con-junctival flap covering combined operation, orally Longdan Xiegan Decoction of Chinese medicine treatment group on the basis of the control group. Symptoms and ulcer and visual acuity were observed in two groups. RESULTS Corneal irritation symptoms and eyesight of two groups ’ patients improved to some degree after treatment. Chinese medicine treatment group of 46 cases, 36 cases were cured, 8 cases improved, 2 cases ineffective, the cure rate was 78.26%, the total efficiency of 95.65%;control group of 38 cases, 21 cases were cured, 10 cases improved, 7 cases ineffective, cure rate was 55.26%, the total efficiency of 81.58%;The difference was statistically significant (Mann-Whitney U test,Z=-2.393,P=0.017). Follow up of 12 months to 18 months, Chinese medicine treatment group cured patients had no recurrence, the control group cured 2 patients relapsed. CONCLUSIONS Based on conventional drugs combined with conjunctival flap covering by increasing Longdan Xiegan Decoction on the treatment, could im-prove the effect of the 0treatment of fungal corneal ulcer.
