CAJ | 학술논문

目的：通过分析近年来本科室双胎妊娠产前诊断结果，以探讨双胎产前诊断的安全性及意义。方法回顾性分析2011年1月1日至2014年2月28日于广东省妇幼保健院医学遗传中心行介入性产前诊断的174例双胎妊娠孕妇资料，分析其产前诊断指征、结果及结局。结果①总共对283个胎儿取样，共检出29个异常，异常检出率10．2％（29／283）。其中胎儿预后不良异常15个，异常率5．3％（15／283）。②绒穿组／羊穿组／脐穿组术后2周内流产率分别为0．0％（0／7）、1．3％（2／149）、0．0％（0／18）；双胎总流产率分别为14．3％（1／7）、3．4％（5／149）、0．0％（0／18）。结论介入性产前诊断技术能有效发现胎儿异常，对于符合产前诊断指征双胎孕妇，告知相关手术风险后仍需建议孕妇行相关介入性产前诊断检查。
목적：통과분석근년래본과실쌍태임신산전진단결과，이탐토쌍태산전진단적안전성급의의。방법회고성분석2011년1월1일지2014년2월28일우광동성부유보건원의학유전중심행개입성산전진단적174례쌍태임신잉부자료，분석기산전진단지정、결과급결국。결과①총공대283개태인취양，공검출29개이상，이상검출솔10．2％（29／283）。기중태인예후불량이상15개，이상솔5．3％（15／283）。②융천조／양천조／제천조술후2주내유산솔분별위0．0％（0／7）、1．3％（2／149）、0．0％（0／18）；쌍태총유산솔분별위14．3％（1／7）、3．4％（5／149）、0．0％（0／18）。결론개입성산전진단기술능유효발현태인이상，대우부합산전진단지정쌍태잉부，고지상관수술풍험후잉수건의잉부행상관개입성산전진단검사。
Objective To investigate the safety of invasive prenatal diagnostic procedures of prenatal diagnosis for twins and its significance.Method This study retrospectively analyzed the 174 twin preg-nancies who took invasive prenatal diagnostic procedures guided by ultrasound in Guangdong Women and children’s hospital from 2011-01-01 to 2014-02-08.The indications,results and outcomes of invasive pre-natal diagnostic procedures were analyzed.Results ①Totally 283 fetus were examined,and there were 29 abnormal results.The abnormal detection rate was 10.2% (29/283 ).There were 15 severely abnormal results.The rate was 5 .3% (15/283).②The fetal loss rate within two weeks after the procedure were 0.0%(0/7)、1 .3% (2/149 )、0.0% (0/18 )respectively in the different group of chorionic villi sampling group/mniocentesis group /cordocentesis group.The total fetal loss rate were 14.3%(1/7 )、3.4%(5/149)、0.0%(0/18)respectively.Conclusions Invasive prenatal diagnostic procedures can find fetus with congenital abnormality effectively.Doctors should advice twin pregnancies who had indications to take in-vasive prenatal diagnostic procedure after warning relative risks.