CAJ | 학술논문

中药水蛭具有破血逐瘀消癥之功，一直以来用于治疗各种血瘀顽疾。随着现代药理学研究进展，水蛭在恶性肿瘤临床治疗中广泛应用，其抗肿瘤作用得到了许多临床及实验研究的证实。本文通过对国内外近年文献的分析、归纳和总结，从抑制肿瘤的生长和增殖、诱导肿瘤细胞凋亡、抑制肿瘤血管生成、抗血小板聚集和抗凝血作用、提高机体免疫力、抗肿瘤多药耐药性几方面归纳了水蛭的抗肿瘤作用机制，并指出目前研究中存在的不足和争议之处，希望能为临床应用及进一步研究提供思路。
중약수질구유파혈축어소징지공，일직이래용우치료각충혈어완질。수착현대약이학연구진전，수질재악성종류림상치료중엄범응용，기항종류작용득도료허다림상급실험연구적증실。본문통과대국내외근년문헌적분석、귀납화총결，종억제종류적생장화증식、유도종류세포조망、억제종류혈관생성、항혈소판취집화항응혈작용、제고궤체면역력、항종류다약내약성궤방면귀납료수질적항종류작용궤제，병지출목전연구중존재적불족화쟁의지처，희망능위림상응용급진일보연구제공사로。
Leech has a broken blood stasis effect and has been used to eliminate a variety of stasis diseases. With the development of modern pharmacology study, in recent years, leeches are widely used in clinical cancer patients, and its anti-tumor effects have been confirmed by numerous clinical and experimental studies. Based on the latest domestic and foreign literature analysis and summary, this article discussed the antitumor mechanisms of leech from the following aspects:inhibition of tumor growth and proliferation, induction of tumor cell apoptosis, inhibition of tumor angiogenesis, anti-platelet aggregation and anti-clotting effect, improvement of immunity, and anti-tumor multi-drug resistance. It also pointed out deficiencies and controversy in current studies, with a purpose to provide ideas for further researches and clinical applications.