CAJ | 학술논문

目的：探讨风痹、寒痹和湿痹方剂用药的配伍规律。方法筛选古籍中治疗风痹、寒痹和湿痹方剂，建立数据库，运用频次分析、假设检验与关联规则分析前30味高频药物，量化方剂性味归经并以此为变量对每类方剂进行聚类分析。结果共收集338首方剂，其中风痹122首、寒痹110首、湿痹106首。3类方剂中前30味高频药物中共有21味相同药物；均以补虚药使用频次最高，其次是风痹发散风寒药、寒痹温里药、湿痹渗湿化湿药。寒痹中肉桂、附子、当归、牛膝、羌活、芍药、黄芪和湿痹中茯苓、白术使用比例明显高于其他两类药物。3类方剂均以微温为主，其次是温、平。每类方剂按药性聚为5个主类时治则分类清晰。结论风、寒、湿痹3类方剂用药相互兼顾又各具特色，多种数据挖掘方法结合能够全面分析痹证治则治法的科学内涵。
목적：탐토풍비、한비화습비방제용약적배오규률。방법사선고적중치료풍비、한비화습비방제，건립수거고，운용빈차분석、가설검험여관련규칙분석전30미고빈약물，양화방제성미귀경병이차위변량대매류방제진행취류분석。결과공수집338수방제，기중풍비122수、한비110수、습비106수。3류방제중전30미고빈약물중공유21미상동약물；균이보허약사용빈차최고，기차시풍비발산풍한약、한비온리약、습비삼습화습약。한비중육계、부자、당귀、우슬、강활、작약、황기화습비중복령、백술사용비례명현고우기타량류약물。3류방제균이미온위주，기차시온、평。매류방제안약성취위5개주류시치칙분류청석。결론풍、한、습비3류방제용약상호겸고우각구특색，다충수거알굴방법결합능구전면분석비증치칙치법적과학내함。
Objective To compare and analyze the formula composition based on their herbal nature for wind, cold, and dampness arthralgia. Methods The ancient formulas for wind, cold, and dampness arthralgia were searched and the database was established. The top 30 high-frequency herbs were analyzed with frequency, hypothesis testing and association rules. The nature, taste, and meridian distribution were used as the variable quantities for clustering analysis. Results Totally 338 formulas were collected, including 122 formulas for wind arthralgia, 110 formulas for cold arthralgia, and 106 formulas for dampness arthralgia. There are 21 same herbs among the top 30 high-frequency herbs;Tonic herbs were the highest frequently used, followed by the divergence of cold herbs in wind arthralgia, interior-warming herbs in cold arthralgia, and damp-resolving herbs in dampness arthralgia. The frequently used herbs in each kind of formula compared with other two kinds were:Cinnamomi Cortex, Aconiti Lateralis Radix Praeparata, Angelicae Sinensis Radix, Achyranthis Bidentatae Radix, Notopterygii Rhizome et Radix, Paeoniae Radix and Astrragali Radix in formulas for cold arthralgia, Poria and Atractylodis Macrocephalae Rhizoma in formulas for dampness arthralgia. Three kinds of formulas are given priority to slight warm, followed by warm and neutral. Classification is clear when most of the formulas were clustered into five classes according to their herbal nature in each kind of formula. Conclusion The three kinds of formulas cross each other but with own characteristics. A variety of data mining methods can be used to analyze scientific connotation of therapeutic principle for arthralgia.