中国脑血管病杂志
中國腦血管病雜誌
중국뇌혈관병잡지
CHINESE JOURNAL OF CEREBROVASCULAR DISEASES
2015年
2期
62-66
,共5页
脑梗死%病死率%根本死亡原因%直接死亡原因
腦梗死%病死率%根本死亡原因%直接死亡原因
뇌경사%병사솔%근본사망원인%직접사망원인
Brain infarction%Case fatality%Underlying cause of death%Direct cause of death
目的:探讨脑梗死住院患者病死率及主要死亡原因。方法回顾性分析2005年1月至2009年12月515例以脑梗死为根本死亡原因的患者的临床资料,计算其住院病死率、直接死亡原因及死因构成比,分析类肝素药物Org10172治疗急性卒中试验( TOAST)分型、年龄、住院病程等临床特点。结果(1)2005年至2009年每年脑梗死住院患者病死率依次为2.0%(91/4659)、2.1%(110/5264)、1.9%(95/5035)、1.2%(100/8656)、1.0%(119/11640),总病死率为1.5%(515/35254),基本呈逐年下降趋势,差异有统计学意义(χ2=42.39,P<0.01)。(2)脑梗死住院患者病死率在青年(<45岁)、中年(45~59岁)、年轻老年(60~74岁)、老年组(>74岁)分别为1.1%(22/2009)、1.0%(112/11158)、1.5%(221/14311)、2.1%(160/7776),随年龄增加而增大(P<0.01)。(3)515例死亡患者TOAST分型依次为:大动脉粥样硬化型57.3%(295例)、心源性栓塞型19.4%(100例)、不明原因型14.4%(74例)、小动脉闭塞型7.0%(36例)、其他原因1 .9%( 1 0例)。前5位直接死因:脑疝49.3%(254例)、原发性中枢性呼吸循环衰竭25.0%(129例)、肺炎8.9%(46例)、脑心综合征5.8%(30例)、多器官功能衰竭5.6%(29例)。(4)平均死亡年龄为(67±12)岁,死于脑疝和原发性中枢性呼吸循环衰竭的患者年龄明显小于死于肺炎者[分别为(65±13)、(68±11)、(75±10)岁,均P<0.01]。住院病程中位数为3.0 d,死于脑疝、原发性中枢性呼吸循环衰竭和脑心综合征的患者住院病程明显短于死于肺炎和多器官功能衰竭患者(住院病程中位数分别为3.0、3.0、3.0、12.5、9.0 d,均P<0.05)。结论脑梗死住院患者病死率呈逐年下降趋势,脑疾病本身是脑梗死患者早期死亡的最主要原因,提示临床工作中应重点防治。
目的:探討腦梗死住院患者病死率及主要死亡原因。方法迴顧性分析2005年1月至2009年12月515例以腦梗死為根本死亡原因的患者的臨床資料,計算其住院病死率、直接死亡原因及死因構成比,分析類肝素藥物Org10172治療急性卒中試驗( TOAST)分型、年齡、住院病程等臨床特點。結果(1)2005年至2009年每年腦梗死住院患者病死率依次為2.0%(91/4659)、2.1%(110/5264)、1.9%(95/5035)、1.2%(100/8656)、1.0%(119/11640),總病死率為1.5%(515/35254),基本呈逐年下降趨勢,差異有統計學意義(χ2=42.39,P<0.01)。(2)腦梗死住院患者病死率在青年(<45歲)、中年(45~59歲)、年輕老年(60~74歲)、老年組(>74歲)分彆為1.1%(22/2009)、1.0%(112/11158)、1.5%(221/14311)、2.1%(160/7776),隨年齡增加而增大(P<0.01)。(3)515例死亡患者TOAST分型依次為:大動脈粥樣硬化型57.3%(295例)、心源性栓塞型19.4%(100例)、不明原因型14.4%(74例)、小動脈閉塞型7.0%(36例)、其他原因1 .9%( 1 0例)。前5位直接死因:腦疝49.3%(254例)、原髮性中樞性呼吸循環衰竭25.0%(129例)、肺炎8.9%(46例)、腦心綜閤徵5.8%(30例)、多器官功能衰竭5.6%(29例)。(4)平均死亡年齡為(67±12)歲,死于腦疝和原髮性中樞性呼吸循環衰竭的患者年齡明顯小于死于肺炎者[分彆為(65±13)、(68±11)、(75±10)歲,均P<0.01]。住院病程中位數為3.0 d,死于腦疝、原髮性中樞性呼吸循環衰竭和腦心綜閤徵的患者住院病程明顯短于死于肺炎和多器官功能衰竭患者(住院病程中位數分彆為3.0、3.0、3.0、12.5、9.0 d,均P<0.05)。結論腦梗死住院患者病死率呈逐年下降趨勢,腦疾病本身是腦梗死患者早期死亡的最主要原因,提示臨床工作中應重點防治。
목적:탐토뇌경사주원환자병사솔급주요사망원인。방법회고성분석2005년1월지2009년12월515례이뇌경사위근본사망원인적환자적림상자료,계산기주원병사솔、직접사망원인급사인구성비,분석류간소약물Org10172치료급성졸중시험( TOAST)분형、년령、주원병정등림상특점。결과(1)2005년지2009년매년뇌경사주원환자병사솔의차위2.0%(91/4659)、2.1%(110/5264)、1.9%(95/5035)、1.2%(100/8656)、1.0%(119/11640),총병사솔위1.5%(515/35254),기본정축년하강추세,차이유통계학의의(χ2=42.39,P<0.01)。(2)뇌경사주원환자병사솔재청년(<45세)、중년(45~59세)、년경노년(60~74세)、노년조(>74세)분별위1.1%(22/2009)、1.0%(112/11158)、1.5%(221/14311)、2.1%(160/7776),수년령증가이증대(P<0.01)。(3)515례사망환자TOAST분형의차위:대동맥죽양경화형57.3%(295례)、심원성전새형19.4%(100례)、불명원인형14.4%(74례)、소동맥폐새형7.0%(36례)、기타원인1 .9%( 1 0례)。전5위직접사인:뇌산49.3%(254례)、원발성중추성호흡순배쇠갈25.0%(129례)、폐염8.9%(46례)、뇌심종합정5.8%(30례)、다기관공능쇠갈5.6%(29례)。(4)평균사망년령위(67±12)세,사우뇌산화원발성중추성호흡순배쇠갈적환자년령명현소우사우폐염자[분별위(65±13)、(68±11)、(75±10)세,균P<0.01]。주원병정중위수위3.0 d,사우뇌산、원발성중추성호흡순배쇠갈화뇌심종합정적환자주원병정명현단우사우폐염화다기관공능쇠갈환자(주원병정중위수분별위3.0、3.0、3.0、12.5、9.0 d,균P<0.05)。결론뇌경사주원환자병사솔정축년하강추세,뇌질병본신시뇌경사환자조기사망적최주요원인,제시림상공작중응중점방치。
Objective To investigate the mortality and cause of death in inpatients with cerebral infarction. Methods The clinical data of 515 patients with cerebral infarction as the underlying cause of death from January 2005 to December 2009 were analyzed retrospectively. The hospital mortality, direct cause of death,and constituent ratio of the cause of death were calculated. The clinical features,such as classification of the Trial of Org 10 172 in acute stroke treatment( TOAST),age and duration of hospital-ization were analyzed. Results ( 1 )The hospital mortalities in patients with cerebral infarction from 2005 to 2009 were 2. 0%(91/4 659),2. 1%(110/5 264),1. 9%(95/5 035),1. 2%(100/8 656),and 1. 0%(119/11 640),respectively. The overall mortality rate was 1. 5%(515/35 254),basically had a declining trend year by year(χ2 =42. 39;P<0. 01).(2)The mortalities of the inpatients with cerebral infarction in the young( <45 years),middle-aged(45 to 59 years),elderly(60 to 74 years),and aged ( >74 years)groups were 1. 1%( 22/2 009 ),1. 0%( 112/11 158 ),1. 5%( 221/14 311 ),and 2. 1%(160/7 776),respectively. They increased with increasing age(P<0. 01).(3)The TOAST classification in 515 died patients were as follows:57. 3%(n=295)for large-artery atherosclerosis,19. 4%(n=100) for cardioembolism,14. 4%(n=74)for cryptogenic stroke,7. 0%(n=36)for small-artery occlusion and 1. 9%(n=10)for other reasons. The five leading direct cause of death were cerebral hernia 49. 3%(n=254),primary central respiratory and circulatory failure 25.0%(n=129),pneumonia 8. 9%(n =46), cerebral-cardiac syndrome 5. 8%( n =30 ),and multiple organ failure 5. 6%( n =29 ).( 4 ) The mean age of death was 67 ± 12 years old. The patients who died of cerebral hernia and primary central respiratory and circulatory failure were younger than those who died of pneumonia(65 ± 13,68 ± 11,and 75 ± 10,respectively;all P<0. 01). The median length of hospital stay was 3 days. The length of hospital stay in patients who died of hernia,primary central respiratory and circulatory failure,and cerebral-cardiac syndrome were significantly shorter than those who died of pneumonia and multiple organ failure( the median length of hospital stay was 3. 0,3. 0,3. 0,12. 5,and 9. 0 days,respectively;all P <0. 05). Conclusions The mortality of hospitalized patients with cerebral infarction have a declining trend year by year. Brain disease itself is the most important reason of early death for patients with cerebral infarction, indicating that it is the important point of prevention and treatment in clinical work.