CAJ | 학술논문

目的：观察胰岛素样生长因子-1（IGF-1）及其受体（IGFR-1）信号通路在前列腺癌中的作用。方法取50例前列腺癌患者石蜡包埋的前列腺癌组织（前列腺癌组），标本经行根治性前列腺切除术留取；并与50例良性前列腺增生组织（良性前列腺增生组）对照，标本经行尿道前列腺电切除术留取。免疫组化法测定两组前列腺组织IGF-1、IGFR-1蛋白的表达。结果前列腺癌组IGF-1、IGFR-1蛋白的阳性表达率均显著高于良性前列腺增生组（依次为：56%比30%、60%比38%，P<0.05）。前列腺癌组IGF-1、IGFR-1蛋白的阳性表达强度（依次为：0.168±0.016、0.174±0.022OD值）也均显著高于良性前列腺增生组（依次为：0.135±0.024、0.150±0.027OD值）（P<0.01）。相关分析显示，IGF-1/IGFR-1蛋白的阳性表达强度无显著相关性（r=0.242，P>0.05）。结论前列腺癌组织中IGF-1/IGFR-1的表达水平增强，IGF/IGFR信号系统可作为前列腺癌预后的预测指标。
목적：관찰이도소양생장인자-1（IGF-1）급기수체（IGFR-1）신호통로재전렬선암중적작용。방법취50례전렬선암환자석사포매적전렬선암조직（전렬선암조），표본경행근치성전렬선절제술류취；병여50례량성전렬선증생조직（량성전렬선증생조）대조，표본경행뇨도전렬선전절제술류취。면역조화법측정량조전렬선조직IGF-1、IGFR-1단백적표체。결과전렬선암조IGF-1、IGFR-1단백적양성표체솔균현저고우량성전렬선증생조（의차위：56%비30%、60%비38%，P<0.05）。전렬선암조IGF-1、IGFR-1단백적양성표체강도（의차위：0.168±0.016、0.174±0.022OD치）야균현저고우량성전렬선증생조（의차위：0.135±0.024、0.150±0.027OD치）（P<0.01）。상관분석현시，IGF-1/IGFR-1단백적양성표체강도무현저상관성（r=0.242，P>0.05）。결론전렬선암조직중IGF-1/IGFR-1적표체수평증강，IGF/IGFR신호계통가작위전렬선암예후적예측지표。
Objective To investigate the potential roles of insulin-like growth factor-I (IGF-I) and it's type I receptor (IGFR-I) in the prostate neoplastic tissues. Methods Fifty paraffin-embedded prostatic cancer samples (prostatic cancer group) which were obtained by radical prostatectomy were analyzed by using immunohistochem-istry. Other 50 samples of benign prostatic hyperplasia (benign prostatic hyperplasia group) which were obtained by transurethral resection of prostate served as control. Results The positive expression rate of IGF-I and IGFR-I in prostatic cancer group were significantly higher than those in benign prostatic hyperplasia group(56% vs 30%, 60%vs 38%, respectively; P all <0.05). The expression levels of them in prostatic cancer group (0.168±0.016; 0.174± 0.022 optical density,respectively) were dramatically higher than those in benign prostatic hyperplasia group (0.135 ±0.024; 0.150 ±0.027 optical density, respectively; all P<0.01). There was no statistic correlation between IGF-1 and IGFR-1 expression in two groups(r=0.242,P>0.05). Conclusion Levels of IGF-1 and IGFR-1 expres-sion are elevated in prostatic cancer tissue. These findings indicate IGF/IGFR-1 signal pathway could serve to pre-dict the outcome of prostatic cancer.