CAJ | 학술논문

目的：分析 N 端脑利钠肽前体(NT proBNP)水平与患者再住院率及生存率的关系，探讨 NT proBNP水平对慢性心力衰竭患者长期预后的预测价值。方法选取2010年1月—2012年5月确诊为慢性心力衰竭的老年患者(60岁以上)共192例进行研究。所有患者均给予适当的抗心力衰竭治疗，比较治疗前后不同心功能分级患者的血浆 NT proBNP水平变化情况；并根据NT proBNP水平由低至高将患者分为3组(A、B、C)，随访两年，比较3组患者的再住院率及生存率，研究NT proBNP与患者再住院率及生存率的关系。结果治疗前，心力衰竭心功能分级越高，其 NT proBNP水平越高，但经抗心力衰竭治疗后 NT proBNP水平均显著降低(P<0.01)；A组低NT proBNP水平患者的再住院率最低，生存率最高，与B组、C组比较差异有统计学意义(P<0.01)；NT proBNP水平与患者的再住院率呈正相关(P<0.05)，而与患者的生存率则呈负相关(P<0.05)。结论 NT proBNP与慢性心力衰竭患者的再住院率及生存率密切相关，能为老年慢性心力衰竭患者预后评估及临床疗效评估提供客观的依据。
목적：분석 N 단뇌리납태전체(NT proBNP)수평여환자재주원솔급생존솔적관계，탐토 NT proBNP수평대만성심력쇠갈환자장기예후적예측개치。방법선취2010년1월—2012년5월학진위만성심력쇠갈적노년환자(60세이상)공192례진행연구。소유환자균급여괄당적항심력쇠갈치료，비교치료전후불동심공능분급환자적혈장 NT proBNP수평변화정황；병근거NT proBNP수평유저지고장환자분위3조(A、B、C)，수방량년，비교3조환자적재주원솔급생존솔，연구NT proBNP여환자재주원솔급생존솔적관계。결과치료전，심력쇠갈심공능분급월고，기 NT proBNP수평월고，단경항심력쇠갈치료후 NT proBNP수평균현저강저(P<0.01)；A조저NT proBNP수평환자적재주원솔최저，생존솔최고，여B조、C조비교차이유통계학의의(P<0.01)；NT proBNP수평여환자적재주원솔정정상관(P<0.05)，이여환자적생존솔칙정부상관(P<0.05)。결론 NT proBNP여만성심력쇠갈환자적재주원솔급생존솔밀절상관，능위노년만성심력쇠갈환자예후평고급림상료효평고제공객관적의거。
Objective To investigate the relationship between the level of the N terminal pro brain natriuretic peptide (NT proBNP) with the readmission and survival rates,and to investigate the long term prognosis predictive value of NT proBNP level in patients with chronic heart failure(CHF).Methods One hundred and ninety two elderly patients with CHF were given appropriate anti heart failure treatment.Before and after treatment,compared the changes of plasma NT proBNP level in patients with various cardi-ac function.And divided the patients into group A,group B and group C according to the level of NT proBNP from low to high.Fol-lowed up for two years,compared the readmission and survival rates of the three groups of patients.So that researched the rela-tionship between the NT proBNP with readmission and survival rates which could provide an objective basis for the risk assessment of prognosis and efficacy in patients.Results Before treatment,the higher cardiac function of heart failure,the higher level of NT proBNP.But after the anti heart failure treatment,the NT proBNP level was significantly lower which difference was significant(P<0.01). The readmission rates of group A with low levels of NT ProBNP was the lowest and the survival rates was the highest which has a significant difference compared with group B and C(P<0.01).The NT proBNP level and the readmission rates was positively cor-related (P<0.05).While the NT proBNP level and the survival rate was negative correlation (P<0.05).Conclusion NT proBNP is closely associated with the readmission rate and survival of chronic heart failure which can provide an objective basis for assessing prognosis and clinical evaluation of efficacy in elderly patients with CHF.