CAJ | 학술논문

目的：建立科学有效的现代中药研究体系，是中医药现代化进程中亟待解决的关键问题之一，然而目前从系统和整体水平研究中药的理论和方法均不成熟。方法：本文将综述当前系统药理学的最新进展，阐明如何整合药效学、药动学以及基因、蛋白、药物网络分析等技术，形成一个完整的可供中药药理学、药效学预测和验证的技术体系。结果：重点从中药基础理论、复方解析、注射液的研究、老方优化和新药开发方面介绍系统药理学在中医药中的应用。结论：本文提出的系统药理学研究体系为中药的现代研究提供了新方法学，将有助于系统、深刻地从系统水平和分子水平揭示中药和机体的相互作用机制，从而指导中药新药研发。
목적：건립과학유효적현대중약연구체계，시중의약현대화진정중극대해결적관건문제지일，연이목전종계통화정체수평연구중약적이론화방법균불성숙。방법：본문장종술당전계통약이학적최신진전，천명여하정합약효학、약동학이급기인、단백、약물망락분석등기술，형성일개완정적가공중약약이학、약효학예측화험증적기술체계。결과：중점종중약기출이론、복방해석、주사액적연구、로방우화화신약개발방면개소계통약이학재중의약중적응용。결론：본문제출적계통약이학연구체계위중약적현대연구제공료신방법학，장유조우계통、심각지종계통수평화분자수평게시중약화궤체적상호작용궤제，종이지도중약신약연발。
Objective:To establish a scientific and effective research system for modern Chinese medicine.However,the current theory and measurement methods of systems analysis of TCM are still in its infant state.Methods:The new advances of system pharmacology (SP),its practical application in investigating the basic theory of TCM,optimization of old formulae and the discovery of new drugs were covered in this study.Results:Drug pharmacokinetics,efficacy,as well as systems biology were integrated into TCMSP.Conclusion:TCMSP will be a valuable tool to help the understanding of the interaction mechanism of TCM and human body at a systematic /molecular level,so as to guide the discovery of new drugs of TCM.