CAJ | 학술논문

目的：分析常用安神类中成药的处方用药规律。方法：收集《新编国家中成药》中的安神类药品处方，基于中医传承辅助系统建立处方数据库，采用关联规则apriori算法、复杂系统熵聚类等方法开展研究，确定处方中各种药物的使用频次及药物之间的关联规则等。结果：高频次药物包括茯苓、甘草、当归、麦冬、朱砂等；高频次药物组合包括“当归、茯苓”“茯苓、炒酸枣仁”“甘草、茯苓”等；置信度较高的关联规则包括“牛黄、朱砂”“酸枣仁、茯苓”等，新处方包括“茯苓、炒酸枣仁、熟地黄、五味子、丹参、麦冬、生地黄”等。结论：安神类中成药处方药物多具有养血定志，补气滋阴和重镇安神之功效。
목적：분석상용안신류중성약적처방용약규률。방법：수집《신편국가중성약》중적안신류약품처방，기우중의전승보조계통건립처방수거고，채용관련규칙apriori산법、복잡계통적취류등방법개전연구，학정처방중각충약물적사용빈차급약물지간적관련규칙등。결과：고빈차약물포괄복령、감초、당귀、맥동、주사등；고빈차약물조합포괄“당귀、복령”“복령、초산조인”“감초、복령”등；치신도교고적관련규칙포괄“우황、주사”“산조인、복령”등，신처방포괄“복령、초산조인、숙지황、오미자、단삼、맥동、생지황”등。결론：안신류중성약처방약물다구유양혈정지，보기자음화중진안신지공효。
Objective:To explore composition rules of TCM tranquilizer prescriptions.Methods:The tranquilizer prescriptions in“The New National Medicine”were collected to build a database based on traditional Chinese medicine inheritance assist system. The methods of association rules with apriori algorithm and complex system entropy cluster were used to achieve the frequency of medicines and association rules between drugs.Results:The data-mining results indicated that in the tranquilizer prescriptions,the highest frequently used drugs were Poria Cocos Wolff,Radix Glycyrrhizae,Angelica sinensis,Radix Ophiopogonis,Cinnabaris. The most frequent drug combinations were “Angelica sinensis,Poria Cocos Wolff”,“Poria Cocos Wolff,Parched Semen Ziziphi Spinosae”,“Radix Glycyrrhizae,Poria Cocos Wolff”.The drugs with a high degree confidence coefficient of association rules in-cluded “Calculus Bovis,Cinnabaris”,“Semen Ziziphi Spinosae,Poria Cocos Wolff”.The new prescriptions contained Poria Co-cos Wolff,Parched Semen Ziziphi Spinosae,Radix Rehmanniae Preparata,Fructus Schisandrae Chinensis,Radix Salviae Miltior-rhizae,Radix Ophiopogonis,and Radix Rehmanniae Exsiccata.Conclusion:Chinese medicine drugs in tranquilizer prescriptions usually have the effects of nourishing the blood,calming mind,benefiting the qi,replenishing the yin and quieting the spirit.