生物加工过程
生物加工過程
생물가공과정
CHINESE JOURNAL OF BIOPROCESS ENGINEERING
2015年
1期
258-260
,共3页
司进辉%任晓%张彦廷
司進輝%任曉%張彥廷
사진휘%임효%장언정
糖尿病/并发症%醛糖还原酶%高通量筛选%平糖舒目散
糖尿病/併髮癥%醛糖還原酶%高通量篩選%平糖舒目散
당뇨병/병발증%철당환원매%고통량사선%평당서목산
Diabetes%Complications%Aldose reductase%Hign-flux screening%Pingtang Shumu powder
目的:通过醛糖还原酶高通量模型对中药方剂平糖舒目散的筛选,探寻其治疗糖尿病的作用机制。方法:用高通量醛糖还原酶筛模型来筛选平糖舒目散,研究方剂平糖舒目散对醛糖还原酶的抑制作用。结果:平糖舒目散对醛糖还原酶有较强的抑制作用,其半数抑制浓度是0.8 g/L。结论:中药方剂平糖舒目散治疗糖尿病慢性并发症的作用机制之一是抑制醛糖还原酶活性。
目的:通過醛糖還原酶高通量模型對中藥方劑平糖舒目散的篩選,探尋其治療糖尿病的作用機製。方法:用高通量醛糖還原酶篩模型來篩選平糖舒目散,研究方劑平糖舒目散對醛糖還原酶的抑製作用。結果:平糖舒目散對醛糖還原酶有較彊的抑製作用,其半數抑製濃度是0.8 g/L。結論:中藥方劑平糖舒目散治療糖尿病慢性併髮癥的作用機製之一是抑製醛糖還原酶活性。
목적:통과철당환원매고통량모형대중약방제평당서목산적사선,탐심기치료당뇨병적작용궤제。방법:용고통량철당환원매사모형래사선평당서목산,연구방제평당서목산대철당환원매적억제작용。결과:평당서목산대철당환원매유교강적억제작용,기반수억제농도시0.8 g/L。결론:중약방제평당서목산치료당뇨병만성병발증적작용궤제지일시억제철당환원매활성。
Objective:To explore the mechanism of Chinese prescription Pingtang Shumu powder in treating diabetes by screening it in high-flux aldose reductase models.Methods:High-flux aldose reductase model was used to screen Pingtang Shumu powder,so as to study on its exhibition effect on aldose reductase.Results:Pingtang Shumu powder had strong exhibition effect on aldose re-ductase with the Icso of 0.8g/L.Conclusion:The mechanism of Chinese prescription of Pingtang Shumu powder treating chronic complications of diabetes is to exhibit the activity of aldose reductase.