CAJ | 학술논문

目的：观察扶正防癌方联合化疗对晚期结肠癌患者生活质量及免疫功能的影响。方法：将符合入选标准的66例患者随机分为治疗组和对照组，对照组给予FOLFOX4方案化疗和对症支持治疗，治疗组在上述治疗的基础上使用FZFA，比较2组患者近期客观有效率、稳定率和生活质量；2组患者外周血CD4＋T淋巴细胞中Th17／Treg细胞百分比及比值；以及2组人血液炎性细胞因子表达水平。结果：2组患者近期客观有效率、稳定率和生活质量改变，患者外周血CD4＋T淋巴细胞中Th17／Treg细胞百分比及比值，以及外周血以及炎性细胞因子表达水平均有统计学意义（P＜0．05）。结论：扶正防癌方联合化疗药物和单纯化疗药物对晚期结肠癌患者均可改善免疫功能，减轻不良反应，提高生活质量，但前者明显优于后者。
목적：관찰부정방암방연합화료대만기결장암환자생활질량급면역공능적영향。방법：장부합입선표준적66례환자수궤분위치료조화대조조，대조조급여FOLFOX4방안화료화대증지지치료，치료조재상술치료적기출상사용FZFA，비교2조환자근기객관유효솔、은정솔화생활질량；2조환자외주혈CD4＋T림파세포중Th17／Treg세포백분비급비치；이급2조인혈액염성세포인자표체수평。결과：2조환자근기객관유효솔、은정솔화생활질량개변，환자외주혈CD4＋T림파세포중Th17／Treg세포백분비급비치，이급외주혈이급염성세포인자표체수평균유통계학의의（P＜0．05）。결론：부정방암방연합화료약물화단순화료약물대만기결장암환자균가개선면역공능，감경불량반응，제고생활질량，단전자명현우우후자。
Objective:To observe the effect of FZFA combined with chemotherapy on life quality and immune function of advanced colorectal cancer patients.Methods:Sixty six patients were randomly divided into treatment group and control group.Patients in the control group were given FOLFOX4 chemotherapy and supportive treatment,and the treatment group using FZFA based on the above treatment.We compared two groups of patients with recent objective efficient and stable rate and quality of life;the percent-age of Th1 7/Treg cells and the ratio of CD4 +T lymphocyte and inflammatory cytokines expression levels in blood of the two groups. Results:The objective response and stable rate and quality of life changes,the percentage of Th1 7/Treg cells and the ratio of CD4 +T lymphocytes in peripheral blood of the two groups,and the expression of peripheral blood and inflammatory cytokine levels had significant difference (P<0. 05 ).Conclusion:FZFA combined with chemotherapy and chemotherapy for advanced colorectal cancer patients can improve immune function,alleviate the adverse reaction,improve the quality of life,but the former is obvious-ly better than the latter.