中国神经精神疾病杂志
中國神經精神疾病雜誌
중국신경정신질병잡지
CHINESE JOURNAL OF NERVOUS AND MENTAL DISEASES
2015年
1期
1-4
,共4页
帕金森病%幻觉%C反应蛋白%白介素6
帕金森病%幻覺%C反應蛋白%白介素6
파금삼병%환각%C반응단백%백개소6
Parkinson disease (PD)%Hallucinations%C-reactive protein (CRP)%Interleukin 6 (IL-6)
目的：通过对帕金森病(Parkinson disease, PD)患者发生幻觉的调查，探讨幻觉的发生率及其影响因素。方法选取神经内科门诊及住院的91例PD患者和38名健康体检者为研究对象。进行简易智力检查量表(mini-mental state examination, MMSE)，综合评分量表第Ⅲ部分(unified Parkinson disease rating scale-Ⅲ, UP?DRS-Ⅲ)以及Hoehn-Yahr分期检查，测量白介素6(interleukin 6, IL-6)和C反应蛋白(C-reactive protein, CRP)。采用帕金森精神症调查问卷(Parkinson psychosis questionnaire, PPQ) B类对PD患者进行分组，PPQ-B≥1分为幻觉组，PPQ-B=0分为无幻觉组。采用logistic回归分析方法探讨其影响因素。结果91例PD患者中有29例出现幻觉，发生率为32%。幻觉组的年龄、IL-6和CRP高于无幻觉组和正常对照组（P<0.05)，幻觉组的病程和MMSE高于无幻觉组(P<0.05)。经Logistic回归分析发现，年龄和病程是幻觉的独立危险因素，比值比(Odds Ratio, OR)分别为1.09(95%CI：1.04～1.32, P<0.05)和1.43(95%CI：1.21～1.87, P<0.05)。炎症因子IL-6每增加1倍，幻觉危险性增加51%(OR=1.51,95%CI：1.13～2.11, P<0.05)，CRP每增加1倍，幻觉危险性增加59%(OR=1.59,95%CI：1.07～2.66, P<0.05)。结论控制血清IL-6和CRP水平，对于延迟或阻止PD患者发生幻觉具有重要意义。
目的：通過對帕金森病(Parkinson disease, PD)患者髮生幻覺的調查，探討幻覺的髮生率及其影響因素。方法選取神經內科門診及住院的91例PD患者和38名健康體檢者為研究對象。進行簡易智力檢查量錶(mini-mental state examination, MMSE)，綜閤評分量錶第Ⅲ部分(unified Parkinson disease rating scale-Ⅲ, UP?DRS-Ⅲ)以及Hoehn-Yahr分期檢查，測量白介素6(interleukin 6, IL-6)和C反應蛋白(C-reactive protein, CRP)。採用帕金森精神癥調查問捲(Parkinson psychosis questionnaire, PPQ) B類對PD患者進行分組，PPQ-B≥1分為幻覺組，PPQ-B=0分為無幻覺組。採用logistic迴歸分析方法探討其影響因素。結果91例PD患者中有29例齣現幻覺，髮生率為32%。幻覺組的年齡、IL-6和CRP高于無幻覺組和正常對照組（P<0.05)，幻覺組的病程和MMSE高于無幻覺組(P<0.05)。經Logistic迴歸分析髮現，年齡和病程是幻覺的獨立危險因素，比值比(Odds Ratio, OR)分彆為1.09(95%CI：1.04～1.32, P<0.05)和1.43(95%CI：1.21～1.87, P<0.05)。炎癥因子IL-6每增加1倍，幻覺危險性增加51%(OR=1.51,95%CI：1.13～2.11, P<0.05)，CRP每增加1倍，幻覺危險性增加59%(OR=1.59,95%CI：1.07～2.66, P<0.05)。結論控製血清IL-6和CRP水平，對于延遲或阻止PD患者髮生幻覺具有重要意義。
목적：통과대파금삼병(Parkinson disease, PD)환자발생환각적조사，탐토환각적발생솔급기영향인소。방법선취신경내과문진급주원적91례PD환자화38명건강체검자위연구대상。진행간역지력검사량표(mini-mental state examination, MMSE)，종합평분량표제Ⅲ부분(unified Parkinson disease rating scale-Ⅲ, UP?DRS-Ⅲ)이급Hoehn-Yahr분기검사，측량백개소6(interleukin 6, IL-6)화C반응단백(C-reactive protein, CRP)。채용파금삼정신증조사문권(Parkinson psychosis questionnaire, PPQ) B류대PD환자진행분조，PPQ-B≥1분위환각조，PPQ-B=0분위무환각조。채용logistic회귀분석방법탐토기영향인소。결과91례PD환자중유29례출현환각，발생솔위32%。환각조적년령、IL-6화CRP고우무환각조화정상대조조（P<0.05)，환각조적병정화MMSE고우무환각조(P<0.05)。경Logistic회귀분석발현，년령화병정시환각적독립위험인소，비치비(Odds Ratio, OR)분별위1.09(95%CI：1.04～1.32, P<0.05)화1.43(95%CI：1.21～1.87, P<0.05)。염증인자IL-6매증가1배，환각위험성증가51%(OR=1.51,95%CI：1.13～2.11, P<0.05)，CRP매증가1배，환각위험성증가59%(OR=1.59,95%CI：1.07～2.66, P<0.05)。결론공제혈청IL-6화CRP수평，대우연지혹조지PD환자발생환각구유중요의의。
Objective To investigate the incidence and risk factors of hallucination in patients with Parkinson’s disease (PD) by using a questionnaire. Methods Ninety-one patients with PD from outpatient and inpatient departments of Neurology and 38 healthy subjects were recruited. Mini-mental state examination (MMSE), unified Parkinson's disease rating scale-Ⅲ(UPDRS-Ⅲ), Hoehn-Yahr, interleukin 6 (IL-6) and C-reactive protein (CRP) were examined in all PD. According to the PPQ-B scores, the PD patients were divided into two groups:the hallucination group (PPQ-B≥1) and non-hallucination group (PPQ-B=0). Logistic regression model was used to explore the risk factors. Results Twen?ty-nine of 91 patients had hallucination and the incidence was 32%. Age and the levels of IL-6 and CRP were signifi?cantly higher in hallucination group than in non-hallucination group. Meanwhile, the duration of illness and MMSE were significantly higher in hallucination group than in non-hallucination group. Logistic regression revealed that the age and duration of illness were independent risk factors of hallucination and the Odds Ratios (OR) were 1.09 (95% CI:1.04~1.32, P<0.05) and 1.43 (95%CI:1.21~1.87, P<0.05), respectively. The risk of hallucination increased by 51%and 59%for each doubling of IL-6 and CRP levels in PD patients and the ORs were 1.51 (95%CI:1.13~2.11, P<0.05) and 1.59 (95%CI:1.07~2.66, P<0.05), respectively. Conclusions Controlling the levels of serum IL-6 and CRP plays an impor?tant role in delay or prevention of the hallucination of PD patients.
