CAJ | 학술논문

目的：探讨尼莫地平对高血压脑出血患者血肿、水肿及神经功能恢复的影响。方法选择我院2013年1～12月收治的高血压脑出血患者84例，随机分为研究组和对照组，各42例，对照组患者给予传统脱水、止血、抗炎、降压治疗，研究组患者在对照组治疗的基础上给予尼莫地平治疗；全部患者治疗3周后进行CT检查，观察血肿及周围水肿带体积变化情况，比较治疗前后神经功能缺损评分改善情况，评价治疗效果。结果治疗后两组血肿体积、水肿体积较治疗前减小，神经功能缺损评分较治疗前降低，前后差异有统计学意义（P＜0.05），但研究组血肿体积、水肿体积、神经功能缺损评分明显小（低）于对照组（P＜0.05）。研究组治疗总有效率明显高于对照组，差异有统计学意义（P＜0.05）。结论尼莫地平辅助治疗高血压脑出血能有效减轻血肿及周围水肿，促进神经功能的恢复，对提高治疗效果有积极作用，值得应用。
목적：탐토니막지평대고혈압뇌출혈환자혈종、수종급신경공능회복적영향。방법선택아원2013년1～12월수치적고혈압뇌출혈환자84례，수궤분위연구조화대조조，각42례，대조조환자급여전통탈수、지혈、항염、강압치료，연구조환자재대조조치료적기출상급여니막지평치료；전부환자치료3주후진행CT검사，관찰혈종급주위수종대체적변화정황，비교치료전후신경공능결손평분개선정황，평개치료효과。결과치료후량조혈종체적、수종체적교치료전감소，신경공능결손평분교치료전강저，전후차이유통계학의의（P＜0.05），단연구조혈종체적、수종체적、신경공능결손평분명현소（저）우대조조（P＜0.05）。연구조치료총유효솔명현고우대조조，차이유통계학의의（P＜0.05）。결론니막지평보조치료고혈압뇌출혈능유효감경혈종급주위수종，촉진신경공능적회복，대제고치료효과유적겁작용，치득응용。
Objective To investigate the influence of Nimodipine on restoration of cerebral haematoma,edema and neurological function of patients with hypertensive cerebral hemorrhage. Methods 84 case of patients with hypertensive cerebral hemorrhage in our hospital from January to December 2013 were randomly divided into research group and control group,42 cases in the control group were given conventional dehydration,hemostasis,anti-inflammatory,antihypertensive treatment,research group was given nimodipine treatment on the basis of control group. After three weeks treatment,all patients were given CT scan,cerebral haematoma and edema volume changes were observed,before and after treatment,neurological deficit scores were compared,and therapeutic effect of two groups were evaluated. Results After treatment,hematoma,edema volume and neurological deficit scores of two groups were decreased,the differences were significant(P < 0.05).But the cerebral haematoma volume,cerebral edema volume,neurological deficit scores of research group were significantly smaller(lower)than the control group (P < 0.05).The total efficiency rate of research group was significantly higher than control group,the difference was significant (P < 0.05). Conclusion In treatment of hypertensive cerebral hemorrhage, nimodipine can effectively reduce cerebral hematoma ,edema volume,and can promote the restoration of neurological function,has positive role in improving the treatment effect,it is worth of application.