CAJ | 학술논문

目的：了解海南地区输血前患者血型不规则抗体的发生频率和分布特点。方法选择2012年1月至2014年6月海南地区各医院送检的439例疑难配血标本，采用盐水法、凝聚胺法和抗人球蛋白法进行血型不规则抗体筛查和抗体特异性鉴定。结果439例送检标本中，共检出血型不规则抗体32例，阳性率7．29％。女性患者不规则抗体的检出率（10．19％）明显高于男性患者（4．72％），差异有统计学意义（χ2＝4．833，P＜0．05）。检出的不规则抗体包括同种特异性抗体13例，自身抗体14例和非特异性不规则抗体5例。各系统疾病中，以血液系统疾病患者检出不规则抗体的比例最高，达到78．13％。结论输血前不规则抗体筛查，对于保证患者输血安全、减少溶血性输血反应发生具有重要意义。
목적：료해해남지구수혈전환자혈형불규칙항체적발생빈솔화분포특점。방법선택2012년1월지2014년6월해남지구각의원송검적439례의난배혈표본，채용염수법、응취알법화항인구단백법진행혈형불규칙항체사사화항체특이성감정。결과439례송검표본중，공검출혈형불규칙항체32례，양성솔7．29％。녀성환자불규칙항체적검출솔（10．19％）명현고우남성환자（4．72％），차이유통계학의의（χ2＝4．833，P＜0．05）。검출적불규칙항체포괄동충특이성항체13례，자신항체14례화비특이성불규칙항체5례。각계통질병중，이혈액계통질병환자검출불규칙항체적비례최고，체도78．13％。결론수혈전불규칙항체사사，대우보증환자수혈안전、감소용혈성수혈반응발생구유중요의의。
Objective To explore the incidence and distribution characteristics of irregular erythrocyte anti‐bodies in pre‐transfusion patients in Hainan area .Methods From November 2012 to March 2014 ,439 blood samples of difficult matching patients were collected from hospitals in Hainan .Saline agglutination test ,polybrene test and an‐ti‐human globulin test were used in the screening of irregular erythrocyte antibodies and the idetification of antibody specificity .Results A total of 32 irregular erythrocyte antibodies were detected in 439 patients ,the positive rate was 7 .29% .The detection rate of irregular erythrocyte antibodies in female patients (10 .19% ) was significant higher than 4 .72% in male patients(χ2 =4 .833 ,P<0 .05) .Among 32 positive irregular erythrocyte antibodies ,including 13 case of specificity allo‐antibodies ,14 cases of auto‐antibodies and 5 cases of non‐specific irregular antibodies .The highest irregular erythrocyte antibodies positive rate (78 .13% ) was observed in hematological disease patients .Conclusion Screening of irregular erythrocyte antibodies before transfusion is important to ensure the safety of blood transfusion and avoid hemolytic transfusion reactions .