CAJ | 학술논문

目的：探讨高频通气联合肺表面活性物质治疗新生儿呼吸窘迫综合征（N RDS ）的临床疗效。方法收集2012年3至2014年3月于长沙市妇幼保健院接受治疗的NRDS患儿64例，分为观察组与对照组各32例，其中对照组给予常频通气联合肺表面活性物质治疗；观察组给予高频通气联合肺表面活性物质治疗，分析临床疗效。结果高频通气联合肺表面活性物质治疗NRDS的临床有效率为93．75％，高于对照组的81．23％，差异有统计学意义（P＜0．05）。并且患儿症状减轻时间、机械辅助通气时间及住院时间均明显短于对照组，差异有统计学意义（P＜0．05）。治疗后两组患儿氧分压（PaO2）、二氧化碳分压（PaCO2）、pH结果均优于治疗前，差异有统计学意义（P＜0．05），且观察组PaO2、PaCO2、pH结果明显优于对照组，差异有统计学意义（P＜0．05）。对照组患儿并发症发生率为50．00％，明显高于观察组的25．00％，差异有统计学意义（ P＜0．05）。结论高频通气联合肺表面活性物质治疗NRDS临床疗效明显，同时可有效改善血气指标，降低并发症的发生率，值得临床推广。
목적：탐토고빈통기연합폐표면활성물질치료신생인호흡군박종합정（N RDS ）적림상료효。방법수집2012년3지2014년3월우장사시부유보건원접수치료적NRDS환인64례，분위관찰조여대조조각32례，기중대조조급여상빈통기연합폐표면활성물질치료；관찰조급여고빈통기연합폐표면활성물질치료，분석림상료효。결과고빈통기연합폐표면활성물질치료NRDS적림상유효솔위93．75％，고우대조조적81．23％，차이유통계학의의（P＜0．05）。병차환인증상감경시간、궤계보조통기시간급주원시간균명현단우대조조，차이유통계학의의（P＜0．05）。치료후량조환인양분압（PaO2）、이양화탄분압（PaCO2）、pH결과균우우치료전，차이유통계학의의（P＜0．05），차관찰조PaO2、PaCO2、pH결과명현우우대조조，차이유통계학의의（P＜0．05）。대조조환인병발증발생솔위50．00％，명현고우관찰조적25．00％，차이유통계학의의（ P＜0．05）。결론고빈통기연합폐표면활성물질치료NRDS림상료효명현，동시가유효개선혈기지표，강저병발증적발생솔，치득림상추엄。
Objective To investigate the clinical effect of high frequency ventilation combined with pulmonary surfactant in treatment of neonatal respiratory distress syndrome (NRDS) .Methods A total of 64 children with NRDS in March 2012 to March 2014 in Maternal and Child Health Hospital of Changsha were randomly divided into observation group and control group ,32 children in each group .Children in the control group were given normal fre‐quency ventilation combined with pulmonary surfactant for treatment while children in the observation group were given high frequency ventilation combined with pulmonary surfactant therapy ,then analyzed clinical effected . Results The clinical efficiency of observation group was 93 .75% ,which was higher than 81 .23% of the control group (P<0 .05) .And the time of symptoms remitted ,mechanical ventilation time and length of hospital stay in the observation group were significant shorter than those in the control group ( P< 0 .05 ) .After treatment ,PaO2 , PaCO2 ,pH of children in two groups were better than those before treatment (P<0 .05) ,and those in the observa‐tion group were significant better than those in the control group (P<0 .05) .The incidence of complications of the control group was 50 .00% ,which was significant higher than 25 .00% in the observation group (P<0 .05) .Conclu‐sion High frequency ventilation combined with pulmonary surfactant has a obvious therapeutic effect in treatment of NRDS ,which could effectively improve the blood gas index ,reduce the incidence of complications ,which is worthy of clinical application .