CAJ | 학술논문

目的：探讨2型糖尿病（T2DM）患者血浆甘露聚糖结合凝集素（MBL）水平及其与血糖、糖化血红蛋白（HbA1c）的关系。方法选取T2DM患者及健康人各60例，测定血浆MBL、空腹血糖（FPG）和HbA1c水平，观察MBL水平变化及与FPG、HbA1c的关系。结果 T2DM 患者血浆MBL、FPG、HbA1c水平均高于健康对照组，差异有统计学意义（P＜0．01）；Pearson相关性分析显示，血浆MBL 水平与 HbA1c呈明显正相关（r＝0．257，P＝0．047）。结论 MBL在T2DM患者血浆中明显增高，可能参与了T2DM的发病过程，检测MBL对 T2DM 的诊断和预后具有潜在的临床价值。
목적：탐토2형당뇨병（T2DM）환자혈장감로취당결합응집소（MBL）수평급기여혈당、당화혈홍단백（HbA1c）적관계。방법선취T2DM환자급건강인각60례，측정혈장MBL、공복혈당（FPG）화HbA1c수평，관찰MBL수평변화급여FPG、HbA1c적관계。결과 T2DM 환자혈장MBL、FPG、HbA1c수평균고우건강대조조，차이유통계학의의（P＜0．01）；Pearson상관성분석현시，혈장MBL 수평여 HbA1c정명현정상관（r＝0．257，P＝0．047）。결론 MBL재T2DM환자혈장중명현증고，가능삼여료T2DM적발병과정，검측MBL대 T2DM 적진단화예후구유잠재적림상개치。
Objective To explore the relationship between serum mannose‐binding lectin (MBL ) and blood glucose ,glycosylated hemoglobin (HbA1c) ,in patients with type 2 diabetes mellitus (T2DM ) .Methods A total of 60 T2DM patients (T2DM group) and 60 healthy persons(control group) were selected in this study .Fasting plasma glucose (FPG) ,HbA1c and MBL levels were measured .The change of MBL level and its correlation with FPG and HbA1c were analyzed .Results The levels of MBL ,FPG and HbA1c of patients in T2DM group were significant higher than those of the control group (P<0 .01) .The MBL level was positively correlated with HbA1c (r=0 .257 , P<0 .05) .Conclusion The serum MBL level significantly increases in patients with T 2DM ,which suggests that MBL might involved in the pathogenesis of T 2DM ,and has potential clinical value in the diagnosis and prognosis of T2DM .