临床医药实践
臨床醫藥實踐
림상의약실천
PROCEEDING OF CLINICAL MEDICINE
2015年
2期
98-99,100
,共3页
抗甲状腺药物%妊娠合并甲状腺功能亢进%胎儿影响
抗甲狀腺藥物%妊娠閤併甲狀腺功能亢進%胎兒影響
항갑상선약물%임신합병갑상선공능항진%태인영향
antithyroid drugs%pregnant woMen with hyperthyroidisM%fetus
目的：探讨抗甲状腺药物对妊娠合并甲状腺功能亢进患者的治疗效果及对胎儿的影响。方法：选取2009年5月—2014 年5月收治的妊娠合并甲状腺功能亢进患者96例，随机分成对照组和观察组，每组48例。对照组患者不接受抗甲状腺药物治疗，观察组接受抗甲状腺药物治疗。对两组患者甲状腺功能、孕妇并发症以及新生儿平均体重和1 Min Apgar 评分进行分析比较。结果：观察组患者的游离三碘甲状腺原氨酸（FT3）、游离甲状腺激素（FT4）以及血清促甲状腺激素（TSH）水平均显著低于对照组；观察组并发症发生率显著低于对照组，差异均有统计学意义（P ﹤0.05）。结论：抗甲状腺药物可以显著改善妊娠合并甲状腺功能亢进患者的甲状腺功能，并可增加胎儿体重，提高 Apgar 评分。
目的：探討抗甲狀腺藥物對妊娠閤併甲狀腺功能亢進患者的治療效果及對胎兒的影響。方法：選取2009年5月—2014 年5月收治的妊娠閤併甲狀腺功能亢進患者96例，隨機分成對照組和觀察組，每組48例。對照組患者不接受抗甲狀腺藥物治療，觀察組接受抗甲狀腺藥物治療。對兩組患者甲狀腺功能、孕婦併髮癥以及新生兒平均體重和1 Min Apgar 評分進行分析比較。結果：觀察組患者的遊離三碘甲狀腺原氨痠（FT3）、遊離甲狀腺激素（FT4）以及血清促甲狀腺激素（TSH）水平均顯著低于對照組；觀察組併髮癥髮生率顯著低于對照組，差異均有統計學意義（P ﹤0.05）。結論：抗甲狀腺藥物可以顯著改善妊娠閤併甲狀腺功能亢進患者的甲狀腺功能，併可增加胎兒體重，提高 Apgar 評分。
목적：탐토항갑상선약물대임신합병갑상선공능항진환자적치료효과급대태인적영향。방법：선취2009년5월—2014 년5월수치적임신합병갑상선공능항진환자96례，수궤분성대조조화관찰조，매조48례。대조조환자불접수항갑상선약물치료，관찰조접수항갑상선약물치료。대량조환자갑상선공능、잉부병발증이급신생인평균체중화1 Min Apgar 평분진행분석비교。결과：관찰조환자적유리삼전갑상선원안산（FT3）、유리갑상선격소（FT4）이급혈청촉갑상선격소（TSH）수평균현저저우대조조；관찰조병발증발생솔현저저우대조조，차이균유통계학의의（P ﹤0.05）。결론：항갑상선약물가이현저개선임신합병갑상선공능항진환자적갑상선공능，병가증가태인체중，제고 Apgar 평분。
Objective:To investigate the efficacy of antithyroid drugs on pregnant woMen with hyperthyroidisM and the iM-pact on fetus. Methods:96 cases of pregnant woMen with hyperthyroidisM in our hospital froM May 2009 to May 2014 were se-lected and randoMly divided into control group and observation group,each group 48 cases. Patients in control group were not adMinistrated with anti - thyroid drugs,and patients in observation group were dealed with antithyroid drugs. The thyroid func-tion,the pregnant woMen coMplications,the newborn average weight and the one Minute Apgar scores of two groups were ana-lyzed and coMpared. Results:The FT3,FT4 and TSH levels of observation group were significantly lower than control group(P﹤ 0. 05). The pregnant woMen coMplications rate of observation group was significantly lower than control group(P ﹤ 0. 05). The newborn average weight of observation group was significantly higher than control group,and the Apgar score high of obser-vation group was significantly higher than control group. The differences were statistically significant(P ﹤ 0. 05). Conclusion:For pregnant woMen with hyperthyroidisM,antithyroid drugs can significantly iMprove thyroid function,the newborn average weight and one Minute Apgar scores.
