临床医药实践
臨床醫藥實踐
림상의약실천
PROCEEDING OF CLINICAL MEDICINE
2015年
2期
85-88
,共4页
原发性高血压%颈动脉粥样硬化%相关性
原髮性高血壓%頸動脈粥樣硬化%相關性
원발성고혈압%경동맥죽양경화%상관성
essential hypertension%carotid artery atherosclerosis correlation
目的:通过观察原发性高血压(EH)患者颈动脉内膜中层厚度(CAIMT)和血清铁蛋白(SF)、游离脂肪酸(FFA)及同型半胱氨酸(HCY)的水平,探讨 EH 患者颈动脉粥样硬化(CAS)与血清 SF,FFA 及 HCY 的相关性。方法:以266例 EH 患者为研究对象,检测 CAIMT(彩色多普勒超声仪)和血清 SF(电化学发光免疫法)、FFA(酶联法)及HCY(循环酶法)水平,据 CAIMT 结果分组后进行统计学对比分析。结果:对照组、CAIMT 非增厚组和 CAIMT 增厚组,三组血清 SF,FFA 及 HCY 水平依次升高,差异有统计学意义(F =69.171,50.492,38.618,P ﹤0.01);CAIMT 增厚组与非增厚组差异具有统计学意义(t =12.561,8.296,4.581,P ﹤0.01);CAIMT 非增厚组与对照组差异也具有统计学意义(t =6.305,4.062,2.913,P ﹤0.01)。CAIMT 分别与血清 SF,FFA 及 HCY 水平具有相关性,呈显著正相关(r =0.597,0.493,0.451;t =9.560,7.279,4.533,P ﹤0.01)。结论:EH 患者体内存在着高水平的 SF,FFA 及 HCY,CAS 的发生与血清 SF,FFA 及 HCY 水平显著相关,改善其水平可能是防治或延缓 EH 合并 CAS 的策略之一。
目的:通過觀察原髮性高血壓(EH)患者頸動脈內膜中層厚度(CAIMT)和血清鐵蛋白(SF)、遊離脂肪痠(FFA)及同型半胱氨痠(HCY)的水平,探討 EH 患者頸動脈粥樣硬化(CAS)與血清 SF,FFA 及 HCY 的相關性。方法:以266例 EH 患者為研究對象,檢測 CAIMT(綵色多普勒超聲儀)和血清 SF(電化學髮光免疫法)、FFA(酶聯法)及HCY(循環酶法)水平,據 CAIMT 結果分組後進行統計學對比分析。結果:對照組、CAIMT 非增厚組和 CAIMT 增厚組,三組血清 SF,FFA 及 HCY 水平依次升高,差異有統計學意義(F =69.171,50.492,38.618,P ﹤0.01);CAIMT 增厚組與非增厚組差異具有統計學意義(t =12.561,8.296,4.581,P ﹤0.01);CAIMT 非增厚組與對照組差異也具有統計學意義(t =6.305,4.062,2.913,P ﹤0.01)。CAIMT 分彆與血清 SF,FFA 及 HCY 水平具有相關性,呈顯著正相關(r =0.597,0.493,0.451;t =9.560,7.279,4.533,P ﹤0.01)。結論:EH 患者體內存在著高水平的 SF,FFA 及 HCY,CAS 的髮生與血清 SF,FFA 及 HCY 水平顯著相關,改善其水平可能是防治或延緩 EH 閤併 CAS 的策略之一。
목적:통과관찰원발성고혈압(EH)환자경동맥내막중층후도(CAIMT)화혈청철단백(SF)、유리지방산(FFA)급동형반광안산(HCY)적수평,탐토 EH 환자경동맥죽양경화(CAS)여혈청 SF,FFA 급 HCY 적상관성。방법:이266례 EH 환자위연구대상,검측 CAIMT(채색다보륵초성의)화혈청 SF(전화학발광면역법)、FFA(매련법)급HCY(순배매법)수평,거 CAIMT 결과분조후진행통계학대비분석。결과:대조조、CAIMT 비증후조화 CAIMT 증후조,삼조혈청 SF,FFA 급 HCY 수평의차승고,차이유통계학의의(F =69.171,50.492,38.618,P ﹤0.01);CAIMT 증후조여비증후조차이구유통계학의의(t =12.561,8.296,4.581,P ﹤0.01);CAIMT 비증후조여대조조차이야구유통계학의의(t =6.305,4.062,2.913,P ﹤0.01)。CAIMT 분별여혈청 SF,FFA 급 HCY 수평구유상관성,정현저정상관(r =0.597,0.493,0.451;t =9.560,7.279,4.533,P ﹤0.01)。결론:EH 환자체내존재착고수평적 SF,FFA 급 HCY,CAS 적발생여혈청 SF,FFA 급 HCY 수평현저상관,개선기수평가능시방치혹연완 EH 합병 CAS 적책략지일。
Objective:To by observing the CAIMT EH patients and seruM SF and FFA and HCY levels,on patients with EH CAS and the correlation of seruM SF and FFA and HCY. Methods:In 266 EH patients as the research object,to detect CAIMT(color doppler ultrasound instruMent)and seruM SF(electrocheMiluMinescence iMMunoassay)and FFA(enzyMe -linked Method)and HCY(circulating enzyMatic)levels,according to the results of CAIMT grouping after statistical coMparison analysis. Results:Control group and CAIMT thickening and thickening of CAIMT group,three groups of SF,and seruM FFA and HCY levels increase,and a significant difference(F = 69. 171,50. 492,38. 618,P ﹤ 0. 01),CAIMT thickening CAIMT is sig-nificantly higher than the thickening group(t = 12. 561,8. 296,4. 581,P ﹤ 0. 01). CAIMT thickening group seruM SF and FFA and HCY levels were significantly higher than control group(t = 6. 305,4. 062,2. 913,P ﹤ 0. 01). CAIMT were positively correlatedwithseruMSFandFFAandHCY,itsgoodcorrelation( r = 0. 597 ,0. 493,0. 451,t = 9. 560,7. 279,4. 533,P ﹤0. 01). Conclusions:EH patients there is a high level of SF,and FFA and HCY,the occurrence of CAS and seruM SF and FFA and significantly related to the level of HCY and iMprove its level May be one of the prevent or delay the strategy of EH coM-bined CAS.