CAJ | 학술논문

目的：探讨吉林人群IL-23R基因rs7517847和rs10489629位点的单核苷酸多态性与强直性脊柱炎易感性的关系。方法：采用PCR-RFLP方法对188例强直性脊柱炎患者进行IL-23 R基因多态性检测，与100例健康者对照分析。结果：两个SNP位点（ rs7517847和rs10489629）各基因型频率和等位基因频率在AS组与对照组之间的分布差异均有统计学意义（P＜0.05），并在假设遗传方式下，rs7517847位点的纯合突变GG基因型与（TG＋TT）基因型比较；rs10489629位点的纯合突变AA基因型与（GA＋GG）基因型比较，其频率分布差异在AS组与对照组之间也具有统计学意义（P＜0.05）。结论：IL-23R基因rs7517847和rs10489629位点的多态性均与吉林人群AS易感性有关；携带G等位基因（或A等位基因）且为GG（或AA）基因型的个体患AS的倾向性增大，可能是患AS的易感因素之一。
목적：탐토길림인군IL-23R기인rs7517847화rs10489629위점적단핵감산다태성여강직성척주염역감성적관계。방법：채용PCR-RFLP방법대188례강직성척주염환자진행IL-23 R기인다태성검측，여100례건강자대조분석。결과：량개SNP위점（ rs7517847화rs10489629）각기인형빈솔화등위기인빈솔재AS조여대조조지간적분포차이균유통계학의의（P＜0.05），병재가설유전방식하，rs7517847위점적순합돌변GG기인형여（TG＋TT）기인형비교；rs10489629위점적순합돌변AA기인형여（GA＋GG）기인형비교，기빈솔분포차이재AS조여대조조지간야구유통계학의의（P＜0.05）。결론：IL-23R기인rs7517847화rs10489629위점적다태성균여길림인군AS역감성유관；휴대G등위기인（혹A등위기인）차위GG（혹AA）기인형적개체환AS적경향성증대，가능시환AS적역감인소지일。
Objective:To investigate the correlation between single nucleotide polymorphism ( SNP ) of rs7517847 and rs10489629 on IL-23R gene and susceptibility of ankylosing spondylitis in Jilin.Methods:IL-23R gene polymorphisms of 188 cases on ankylosing spondylitis were detected by polymerase chain reaction-restriction fragment length polymorphism ( PCR-RFLP ) , compared with those of 100 cases of healthy control group.Results:The frequency distribution differences ,between AS group and comparison group of separate genotype and the allele on two SNPs (rs7517847 and rs10489629) both showed statistical significance (P<0.05).Meanwhile, by the assumed genetic way , compared homozygous mutant GG of rs 7517847 with TG+TT, compared homozygous mutant AA of rs10489629 with GA+GG,such frequency distribution difference between the above two groups also showed statistical significance ( P<0.05).Conclusion:Polymorphisms about IL-23R gene of the rs7517847 and rs10489629 are both associated with susceptibility of AS in Jilin.The risk of AS will be increased if the person both with G/A allele and GG/AA genotype , which may be one of susceptive factors by AS.