中国卒中杂志
中國卒中雜誌
중국졸중잡지
CHINESE JOURNAL OF STROKE
2015年
2期
147-152
,共6页
苏芳%朱雨岚%郭安臣%王拥军%王群
囌芳%硃雨嵐%郭安臣%王擁軍%王群
소방%주우람%곽안신%왕옹군%왕군
缺血预适应%缺血耐受%生物标志物
缺血預適應%缺血耐受%生物標誌物
결혈예괄응%결혈내수%생물표지물
Ischemic preconditioning%Ischemic tolerance%Biomarkers
缺血预适应是一种内源性神经保护机制,即短暂的、非致死缺血损伤保护后续的致死性缺血打击。它通过短暂的缺血诱导固有的防御系统,引起对随后的严重缺血的耐受。预适应存在于多种器官及生物,其中脑缺血预适应受到了广泛的关注。找到适合的标志物以表明预适应反应诱发的缺血耐受是转化研究的重点。理想的标志物应易于获得,有较高的敏感性及特异性。本文将对可能反映缺血预适应诱发的缺血耐受状态的血清及影像学标志物予以综述。
缺血預適應是一種內源性神經保護機製,即短暫的、非緻死缺血損傷保護後續的緻死性缺血打擊。它通過短暫的缺血誘導固有的防禦繫統,引起對隨後的嚴重缺血的耐受。預適應存在于多種器官及生物,其中腦缺血預適應受到瞭廣汎的關註。找到適閤的標誌物以錶明預適應反應誘髮的缺血耐受是轉化研究的重點。理想的標誌物應易于穫得,有較高的敏感性及特異性。本文將對可能反映缺血預適應誘髮的缺血耐受狀態的血清及影像學標誌物予以綜述。
결혈예괄응시일충내원성신경보호궤제,즉단잠적、비치사결혈손상보호후속적치사성결혈타격。타통과단잠적결혈유도고유적방어계통,인기대수후적엄중결혈적내수。예괄응존재우다충기관급생물,기중뇌결혈예괄응수도료엄범적관주。조도괄합적표지물이표명예괄응반응유발적결혈내수시전화연구적중점。이상적표지물응역우획득,유교고적민감성급특이성。본문장대가능반영결혈예괄응유발적결혈내수상태적혈청급영상학표지물여이종술。
Ischemic preconditioning (IPC) is an intrinsic neuroprotective mechanism whereby a brief, sublethal ischemic insult protects against a subsequent lethal ischemic attack. Its basic premise is that brief durations of ischemia induce innate defense systems leading to tolerance of subsequent, more severe ischemia. Preconditioning has been observed in multiple organs and species, among which cerebral ischemic preconditioning had gained much more attention. Finding suitable biomarkers to show the ischemic tolerance induced by ischemic preconditioning is a translational research priority. The ideal biomarker should be easily obtained, with high sensitivity and specificity. In this article, we will review the probable serum and imaging biomarkers for cerebral ischemic tolerance induced by ischemic preconditioning.