广东医学
廣東醫學
엄동의학
GUNAGDONG MEDICAL JOURNAL
2015年
1期
39-42
,共4页
孙鹏涛%黄伯湘%陈其城%杨乐平%沈嫱
孫鵬濤%黃伯湘%陳其城%楊樂平%瀋嬙
손붕도%황백상%진기성%양악평%침장
斑点追踪%二尖瓣环位移%左心室%收缩功能%顿抑心肌
斑點追蹤%二尖瓣環位移%左心室%收縮功能%頓抑心肌
반점추종%이첨판배위이%좌심실%수축공능%돈억심기
speckle tracking%mitral annular displacement%left ventricle%systolic function%stunned myocardium
目的：应用斑点追踪测量二尖瓣环位移（MAD）法评价心肌顿抑犬左心室整体收缩功能的延迟变化。方法制作冠状动脉左前降支阻断后再灌注犬心肌顿抑模型，分为长顿抑组（阻断45 min）、短顿抑组（阻断15 min）和假手术组（不阻断），对阻断前，再灌注即刻，再灌注后10、30、60、90 min 的二尖瓣环位移参数进行比较。结果再灌注即刻，长顿抑组的 EMAD1、EMAD2、EMADm 及 EMADm％值均低于结扎前及假手术组，差异有统计学意义；短顿抑组的 EMAD2、EMADm 及 EMADm％值均低于结扎前及假手术组，差异有统计学意义。再灌注后90 min 时长顿抑组 EMAD1值低于短顿抑组，差异有统计学意义。结论应用斑点追踪测量 MAD 法可准确、便捷评价心肌顿抑犬左心室整体收缩功能的延迟变化。
目的：應用斑點追蹤測量二尖瓣環位移（MAD）法評價心肌頓抑犬左心室整體收縮功能的延遲變化。方法製作冠狀動脈左前降支阻斷後再灌註犬心肌頓抑模型，分為長頓抑組（阻斷45 min）、短頓抑組（阻斷15 min）和假手術組（不阻斷），對阻斷前，再灌註即刻，再灌註後10、30、60、90 min 的二尖瓣環位移參數進行比較。結果再灌註即刻，長頓抑組的 EMAD1、EMAD2、EMADm 及 EMADm％值均低于結扎前及假手術組，差異有統計學意義；短頓抑組的 EMAD2、EMADm 及 EMADm％值均低于結扎前及假手術組，差異有統計學意義。再灌註後90 min 時長頓抑組 EMAD1值低于短頓抑組，差異有統計學意義。結論應用斑點追蹤測量 MAD 法可準確、便捷評價心肌頓抑犬左心室整體收縮功能的延遲變化。
목적：응용반점추종측량이첨판배위이（MAD）법평개심기돈억견좌심실정체수축공능적연지변화。방법제작관상동맥좌전강지조단후재관주견심기돈억모형，분위장돈억조（조단45 min）、단돈억조（조단15 min）화가수술조（불조단），대조단전，재관주즉각，재관주후10、30、60、90 min 적이첨판배위이삼수진행비교。결과재관주즉각，장돈억조적 EMAD1、EMAD2、EMADm 급 EMADm％치균저우결찰전급가수술조，차이유통계학의의；단돈억조적 EMAD2、EMADm 급 EMADm％치균저우결찰전급가수술조，차이유통계학의의。재관주후90 min 시장돈억조 EMAD1치저우단돈억조，차이유통계학의의。결론응용반점추종측량 MAD 법가준학、편첩평개심기돈억견좌심실정체수축공능적연지변화。
Objective To investigative delayed relaxation of left ventricle globe systolic function in stunned myo -cardium by detection of mitral annular displacement (MAD) with two -dimensional speckle tracking imaging .Methods Eighteen open -chest beagle dogs were divided into 3 groups: short time stunned group, long time stunned group and sham operation group.The acute myocardium ischemia was induced by ligating left anterior descending coronary artery for 15 (short time stunned group) or 45(long time stunned group) min.Two -dimensional imaging were obtained at the api -cal four -chamber view before ischemia, and 15 min and 45 min after ischemia, as well as 10, 30, 60 and 90 min after reperfusion.The parameters of MAD were obtained use off -line QLAB software.Results Compared with baseline and with sham operation group, EMAD1, EMAD2, EMADm and EMADm% in long time stunned group were significantly re -duced.Compared with baseline and with sham operation group , EMAD2, EMADm and EMADm% in short time stunned group were also significantly reduced.Compared with short time stunned group , EMAD1 in long time stunned group at the 90 min of reperfusion was significantly reduced .Conclusion Based on two -dimensional speckle tracking imaging , MAD is an accurate and rapid method determining delayed relaxation of LV global systolic function in stunned myocardium .
