CAJ | 학술논문

目的采用弥散张量成像（DTI）技术探索抑郁症患者脑白质微结构完整性情况。方法对21例抑郁症患者和17例健康对照者行常规 MRI 和 DTI 扫描，采用基于体素分析的方法比较两组间各向异性分数（FA）值的差异。结果与健康对照者相比，抑郁症患者主要表现为右侧楔回、右侧距状回、左侧额上回内侧、左侧前扣带回、左侧边缘叶、右侧前额叶、右侧舌回、右侧后扣带和左侧中央前回的 FA 值减少，差异有统计学意义（P ＜0．001）。结论抑郁症患者存在脑内多脑区 FA 值减少，局部白质微结构受损。
목적채용미산장량성상（DTI）기술탐색억욱증환자뇌백질미결구완정성정황。방법대21례억욱증환자화17례건강대조자행상규 MRI 화 DTI 소묘，채용기우체소분석적방법비교량조간각향이성분수（FA）치적차이。결과여건강대조자상비，억욱증환자주요표현위우측설회、우측거상회、좌측액상회내측、좌측전구대회、좌측변연협、우측전액협、우측설회、우측후구대화좌측중앙전회적 FA 치감소，차이유통계학의의（P ＜0．001）。결론억욱증환자존재뇌내다뇌구 FA 치감소，국부백질미결구수손。
Objective The application of diffusion tensor imaging (DTI) was used to explore the white matter in -tegrity in patients with major depressive disorder (MDD).Methods Brain MR imaging using T1, T2 and DTI se-quences was performed in 38 subjects (21 depressed patients and 17 controls).Voxelwise statistical analysis of FA data was performed using voxel -based analysis (VBA).Results In patients with MDD, significant reduction in FA, an un-specific measure of microstructural tissue integrity , were found in the right cunues, right calcarine, the inside of left fron-tal gyrus, left anterior cingulate cortex, left limbic central gyrus, right prefrontal cortex, right lingual gyrus, right posterior cingulated and left precentral gyrus (P <0.001).Conclusion The reduction of FA values in brain suggests white matter microstructure of patients with MDD was impaired .