核苷和核苷酸类药物治疗慢性乙型肝炎的长期性
핵감화핵감산류약물치료만성을형간염적장기성
Long-term treatment of chronic hepatitis B Experts attending the discussion on long-treatment of chronic hepatitis B
  • 万方数据
    实用肝脏病杂志 실용간장병잡지
    JOURNAL OF CLINICAL HEPATOLOGY
    2015年 1期 113-119 ,共7页

    陈成伟%陈士俊%陈永平%成军%程明亮%窦晓光%段钟平%高志良%侯金林%贾继东%江家骥%李杰%李兰娟%李彤%鲁凤民%茅益民%缪晓辉%宁琴%牛俊奇%任红%孙永涛%谭德明%唐红%唐小平%万谟彬%王贵强%王豪%王慧芬%王宇明%魏来%翁心华%谢青%尤红%张文宏%张欣欣%庄辉

    진성위%진사준%진영평%성군%정명량%두효광%단종평%고지량%후금림%가계동%강가기%리걸%리란연%리동%로봉민%모익민%무효휘%저금%우준기%임홍%손영도%담덕명%당홍%당소평%만모빈%왕귀강%왕호%왕혜분%왕우명%위래%옹심화%사청%우홍%장문굉%장흔흔%장휘

    肝炎,乙型,慢性%核苷和核苷酸类药物%长期治疗%管理 肝炎,乙型,慢性%覈苷和覈苷痠類藥物%長期治療%管理
    간염,을형,만성%핵감화핵감산류약물%장기치료%관리
    Hepatitis B,chronic%Nucleoside and nucleotide analogs%Long-term treatment%Management
    核苷和核苷酸类药物（NAs）已成功用于慢性乙型肝炎（CHB）治疗。目前一致认为，乙型肝炎病毒（HBV）复制是肝损伤和疾病进展的关键因素，因此CHB治疗的主要目的是最大限度地持续抑制HBV复制。现已证明，应用NAs长期治疗CHB可明显改善肝脏组织学、逆转肝纤维化或肝硬化，以及减少肝细胞癌的发生。本文对CHB长期治疗的必要性、临床获益及管理进行了综述。
    핵감화핵감산류약물（NAs）이성공용우만성을형간염（CHB）치료。목전일치인위，을형간염병독（HBV）복제시간손상화질병진전적관건인소，인차CHB치료적주요목적시최대한도지지속억제HBV복제。현이증명，응용NAs장기치료CHB가명현개선간장조직학、역전간섬유화혹간경화，이급감소간세포암적발생。본문대CHB장기치료적필요성、림상획익급관리진행료종술。
    Nucleos (t)ide analogs (NAs) have been successfully used for treatment of chronic hepatitis B. Hepatitis B virus (HBV) replication is now recognized as the key driverof liver injury and disease progression, so the primaryaim of treatment forchronic HBV infection is to maximize sustained suppression of HBV replication to undetectablelevels. The long-term treatment has also beenshown to achieve substantial histological improvement and regression of liver fibrosis orcirrhosis,and reduction of hepatocellular carcinoma. This paper has reviewed the necessity, clinical benefits, and the management of long-term treatment for chronic hepatitis B.
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