实用肝脏病杂志
實用肝髒病雜誌
실용간장병잡지
JOURNAL OF CLINICAL HEPATOLOGY
2015年
1期
97-100
,共4页
阮承兰(综述)%陈从新(审校)
阮承蘭(綜述)%陳從新(審校)
원승란(종술)%진종신(심교)
肝损伤%间充质干细胞%膜微粒%治疗
肝損傷%間充質榦細胞%膜微粒%治療
간손상%간충질간세포%막미립%치료
Liver injury%Mesenchymal stem cells%Microvesicles%Treatment
间充质干细胞（mesenchymal stem cells, MSCs）移植是治疗肝硬化和肝衰竭的重要方式。MSCs修复肝损伤的机制主要有三种：干细胞分化为肝细胞样细胞，旁分泌作用和免疫调节功能及膜微粒（microvesicles，MVs)介导的信号传递。目前的研究表明，MVs介导的RNAs传递在组织修复中发挥着至关重要的作用，MVs移植可能成为修复肝损伤的一种新方式。本文重点介绍了移植入肝脏的MSCs可能的作用机制和MVs的生物治疗潜力。
間充質榦細胞（mesenchymal stem cells, MSCs）移植是治療肝硬化和肝衰竭的重要方式。MSCs脩複肝損傷的機製主要有三種：榦細胞分化為肝細胞樣細胞，徬分泌作用和免疫調節功能及膜微粒（microvesicles，MVs)介導的信號傳遞。目前的研究錶明，MVs介導的RNAs傳遞在組織脩複中髮揮著至關重要的作用，MVs移植可能成為脩複肝損傷的一種新方式。本文重點介紹瞭移植入肝髒的MSCs可能的作用機製和MVs的生物治療潛力。
간충질간세포（mesenchymal stem cells, MSCs）이식시치료간경화화간쇠갈적중요방식。MSCs수복간손상적궤제주요유삼충：간세포분화위간세포양세포，방분비작용화면역조절공능급막미립（microvesicles，MVs)개도적신호전체。목전적연구표명，MVs개도적RNAs전체재조직수복중발휘착지관중요적작용，MVs이식가능성위수복간손상적일충신방식。본문중점개소료이식입간장적MSCs가능적작용궤제화MVs적생물치료잠력。
Transplantation of mesenchymal stem cells (MSCs) is an promising way in the treatment of cirrhosis and liver failure. The possible mechanisms of MSCs in repair of liver injury are as follows:differentiation to hepatocyte-like cells,paracrine and immunomodulatory effects,and signal transmission mediated by microvesicles (MVs). Results from present studies suggest that RNA carried by MVs has emerged as an important mechanism by which the stem cells may repair injured cells and MVs trans-plantation may become a new choice for improving decompensated liver functions. This review will discuss the possible mecha-nisms of intrahepatic transplanted MSCs and the potential of MVs in the treatment of liver injuries.
