CAJ | 학술논문

内质网应激（ERS）是由于各种原因引起的内质网中出现错误折叠或未折叠蛋白在腔内聚集以及钙离子平衡紊乱的状态。ERS与各种肝病的发病机制密切相关，因此对ERS进行干预将对肝病的预防和治疗提供新的机会。本文介绍了ERS引起的未折叠蛋白反应及其干预药物在肝病的预防和治疗中可能提供的新的靶点。
내질망응격（ERS）시유우각충원인인기적내질망중출현착오절첩혹미절첩단백재강내취집이급개리자평형문란적상태。ERS여각충간병적발병궤제밀절상관，인차대ERS진행간예장대간병적예방화치료제공신적궤회。본문개소료ERS인기적미절첩단백반응급기간예약물재간병적예방화치료중가능제공적신적파점。
Endoplasmic reticulum (ER) homeostasis is perturbed by various pathological conditions,and a given new syn-thesized unfolded proteins might accumulate in the ER and result in endoplasmic reticulum stress (ERS). ERS is related to the pathogenesis of the various liver diseases,and some scholars believe that the intervention of ERS will provide new choices for prevention and treatment of liver diseases. This paper will review the unfolded protein response due to ERS,which might be the target for medical intervention for liver diseases.