吉林医学
吉林醫學
길림의학
JILIN MEDICAL JOURANL
2015年
6期
1060-1062
,共3页
下肢骨折%深静脉血栓(DVT)%低分子肝素钙%丹参多酚酸盐%预防%效果
下肢骨摺%深靜脈血栓(DVT)%低分子肝素鈣%丹參多酚痠鹽%預防%效果
하지골절%심정맥혈전(DVT)%저분자간소개%단삼다분산염%예방%효과
Lower limb fracture%Deep vein thrombosis%Low molecular heparin calcium%Salvianolate%Prevention%Effect
目的：观察低分子肝素钙联合丹参多酚酸盐预防下肢骨折术后深静脉血栓形成（ DVT）临床效果及安全性。方法：将收治的203例行手术治疗的下肢骨折患者，随机分为观察组（低分子肝素钙联合丹参多酚酸盐）103例，对照组（单用低分子肝素钙）100例，并于术后比较两组预防DVT临床效果。结果：两组术前术后D—二聚体（ D—dimer）、血小板计数、凝血酶原时间（ PT）、纤维蛋白原（FIB）等指标比较均有明显变化，差异显著具有统计学意义（P<0.05），而组间比较，观察组术后14 d D—dimer检测值含量低于对照组，差异具有统计学意义（P<0.05），其余观察指标较对照组虽有变化，但差异无统计学意义（P>0.05）；观察组DVT发生率明显低于对照组，两组比较，差异有统计学意义（P<0.05），两组不良反应发生率比较，差异无统计学意义（P>0.05），表明两组用药方法均可有效预防下肢骨折患者术后DVT发生，而观察组预防效果更优于对照组。结论：低分子肝素钙联合丹参多酚酸盐可有效降低下肢骨折术后DVT发生率，临床预防效果显著，不良反应少，具有较好的安全性。
目的：觀察低分子肝素鈣聯閤丹參多酚痠鹽預防下肢骨摺術後深靜脈血栓形成（ DVT）臨床效果及安全性。方法：將收治的203例行手術治療的下肢骨摺患者，隨機分為觀察組（低分子肝素鈣聯閤丹參多酚痠鹽）103例，對照組（單用低分子肝素鈣）100例，併于術後比較兩組預防DVT臨床效果。結果：兩組術前術後D—二聚體（ D—dimer）、血小闆計數、凝血酶原時間（ PT）、纖維蛋白原（FIB）等指標比較均有明顯變化，差異顯著具有統計學意義（P<0.05），而組間比較，觀察組術後14 d D—dimer檢測值含量低于對照組，差異具有統計學意義（P<0.05），其餘觀察指標較對照組雖有變化，但差異無統計學意義（P>0.05）；觀察組DVT髮生率明顯低于對照組，兩組比較，差異有統計學意義（P<0.05），兩組不良反應髮生率比較，差異無統計學意義（P>0.05），錶明兩組用藥方法均可有效預防下肢骨摺患者術後DVT髮生，而觀察組預防效果更優于對照組。結論：低分子肝素鈣聯閤丹參多酚痠鹽可有效降低下肢骨摺術後DVT髮生率，臨床預防效果顯著，不良反應少，具有較好的安全性。
목적：관찰저분자간소개연합단삼다분산염예방하지골절술후심정맥혈전형성（ DVT）림상효과급안전성。방법：장수치적203례행수술치료적하지골절환자，수궤분위관찰조（저분자간소개연합단삼다분산염）103례，대조조（단용저분자간소개）100례，병우술후비교량조예방DVT림상효과。결과：량조술전술후D—이취체（ D—dimer）、혈소판계수、응혈매원시간（ PT）、섬유단백원（FIB）등지표비교균유명현변화，차이현저구유통계학의의（P<0.05），이조간비교，관찰조술후14 d D—dimer검측치함량저우대조조，차이구유통계학의의（P<0.05），기여관찰지표교대조조수유변화，단차이무통계학의의（P>0.05）；관찰조DVT발생솔명현저우대조조，량조비교，차이유통계학의의（P<0.05），량조불량반응발생솔비교，차이무통계학의의（P>0.05），표명량조용약방법균가유효예방하지골절환자술후DVT발생，이관찰조예방효과경우우대조조。결론：저분자간소개연합단삼다분산염가유효강저하지골절술후DVT발생솔，림상예방효과현저，불량반응소，구유교호적안전성。
Objective Observation Clinical efficacy and safety of low molecular heparin calcium the joint salvianolate lower limb fracture prevention of postoperative deep vein thrombosis( DVT). Method 203 patients underwent surgery for patients with lower limb fractures were randomly divided into the observation group( low molecular heparin calcium joint salvianolate)in 103 cases,the control group( treated with low molecular heparin calcium)in 100 cases,And to compare two groups of postoperative clinical effect preventing DVT. Results Preoperative and postoperative D—dimer,platelet count,prothrombin time( PT),fibrinogen( FIB)etc comparison of indexes of two groups had the obvious change,the difference was statistically significant(P<0. 05),Comparison between groups,14 d D—dimer detection value of the patients in the observation group was lower than those in the control group,with statistical difference( P<0. 05),the rest of the observation index than the control group,although had change,but there was no significant difference( P>0. 05),the incidence of DVT of the observation group was obviously lower than the control group,two groups of comparison the difference was statistically significant( P<0. 05 ),adverse reactions of two groups was no significant difference(P>0. 05),Show that Two groups use medicine to be effective in preventing DVT occurred postopera-tively in patients with lower limb fracture,the observation group to prevent the effect was much better than the control group. Conclusion Low molecular heparin calcium joint salvianolate can effectively reduce the incidence of postoperative lower extremity fracture DVT,Clinical pre-vention effect significant,less adverse reaction,good security.
