中国伤残医学
中國傷殘醫學
중국상잔의학
CHINESE JOURNAL OF TRAUMA AND DISABILITY MEDICINE
2015年
4期
19-21,22
,共4页
郝瑩%吴宝刚%刘宇翔%邵丽匀
郝瑩%吳寶剛%劉宇翔%邵麗勻
학영%오보강%류우상%소려균
高血压%缺血性脑卒中%GPx-3%关联性%交互作用
高血壓%缺血性腦卒中%GPx-3%關聯性%交互作用
고혈압%결혈성뇌졸중%GPx-3%관련성%교호작용
Hypertension%Ischemic Stroke%GPx-3%Association%Interaction
目的：：分析谷胱甘肽过氧化物酶(GPx-3)基因与高血压并缺血性脑卒中的关联性及其与环境因素的交互作用。方法：选择祖辈开始居住于辽宁阜新农村地区的汉族人群,入选高血压患者238例,高血压并缺血性脑卒中患者75例,采用pyrose-quencing ( PSQ)方法进行GPx-3单碱基多态位点rs3828599基因分型,运用logistic回归模型评价rs3828599与高血压并缺血性脑卒中的关联性,进一步运用多因子降维法( MDR)分析在高血压并缺血性脑卒中的发病中rs3828599与环境危险因素之间的交互作用。结果：(1)在共显性、显性和隐性3种遗传模型下,rs3828599与高血压并缺血性脑卒中均无显著关联性。(2)高血压人群中GPx-3基因TC杂合子和CC纯合子携带者,饮酒者,男性,甘油三酯( TG)高于2.25mmol/L者,总胆固醇( TC)高于5.72 mmol/l者合并缺血性脑卒中的风险显著性增加。结论：GPx-3 C等位基因,男性、饮酒、TG及TC升高共同促进高血压患者并发缺血性脑卒中,但是GPx-3基因可能不是主要风险因素。
目的：：分析穀胱甘肽過氧化物酶(GPx-3)基因與高血壓併缺血性腦卒中的關聯性及其與環境因素的交互作用。方法：選擇祖輩開始居住于遼寧阜新農村地區的漢族人群,入選高血壓患者238例,高血壓併缺血性腦卒中患者75例,採用pyrose-quencing ( PSQ)方法進行GPx-3單堿基多態位點rs3828599基因分型,運用logistic迴歸模型評價rs3828599與高血壓併缺血性腦卒中的關聯性,進一步運用多因子降維法( MDR)分析在高血壓併缺血性腦卒中的髮病中rs3828599與環境危險因素之間的交互作用。結果：(1)在共顯性、顯性和隱性3種遺傳模型下,rs3828599與高血壓併缺血性腦卒中均無顯著關聯性。(2)高血壓人群中GPx-3基因TC雜閤子和CC純閤子攜帶者,飲酒者,男性,甘油三酯( TG)高于2.25mmol/L者,總膽固醇( TC)高于5.72 mmol/l者閤併缺血性腦卒中的風險顯著性增加。結論：GPx-3 C等位基因,男性、飲酒、TG及TC升高共同促進高血壓患者併髮缺血性腦卒中,但是GPx-3基因可能不是主要風險因素。
목적：：분석곡광감태과양화물매(GPx-3)기인여고혈압병결혈성뇌졸중적관련성급기여배경인소적교호작용。방법：선택조배개시거주우료녕부신농촌지구적한족인군,입선고혈압환자238례,고혈압병결혈성뇌졸중환자75례,채용pyrose-quencing ( PSQ)방법진행GPx-3단감기다태위점rs3828599기인분형,운용logistic회귀모형평개rs3828599여고혈압병결혈성뇌졸중적관련성,진일보운용다인자강유법( MDR)분석재고혈압병결혈성뇌졸중적발병중rs3828599여배경위험인소지간적교호작용。결과：(1)재공현성、현성화은성3충유전모형하,rs3828599여고혈압병결혈성뇌졸중균무현저관련성。(2)고혈압인군중GPx-3기인TC잡합자화CC순합자휴대자,음주자,남성,감유삼지( TG)고우2.25mmol/L자,총담고순( TC)고우5.72 mmol/l자합병결혈성뇌졸중적풍험현저성증가。결론：GPx-3 C등위기인,남성、음주、TG급TC승고공동촉진고혈압환자병발결혈성뇌졸중,단시GPx-3기인가능불시주요풍험인소。
Objevtive:To analyze the association of GPx-3 and its interaction with environmental factors for hypertension concomitant ischemic stroke. Methods:At Fuxin rural areas, Han people who lived there from ancestor were selected as participation. 238 unrelated hypertensives and 75 hypertensives concomitant ischemic stroke were recruited. We genotyped rs3828599 of GPx-3 with pyrosequencing ( PSQ) . The logistic regression model was used to test the association between rs3828599 and hypertension concomitant ischemic stroke. We evaluated interaction between rs3828599 and risk variant carrier status for hypertension concomitant ischemic stroke with multifactor dimensionality reduction ( MDR) software. Results:1. Under recessive, dominant and codominant genetic model, three genotypes of rs3828599 did not significantly increase the risk of hypertension concomitant ischemic stroke ( P>0. 05) ,neither before nor after adjus-ted confounding factors. 2. Male, drinking status, total cholesterol (TC) and triglyceride (TG) had interaction with rs3828599 for hyper-tension concomitant ischemic stroke. Conclusion:GPx-3, male, drinking, TG and TC synergistically participate the pathogenesis of hy-pertension concomitant ischemic stroke, however, the polymorphism of rs3828599 of GPx-3 gene might not be the main risk factor for hy-pertension concomitant ischemic stroke in rural Han Chinese in Fuxin, Liaoning.
