CAJ | 학술논문

目的：探讨脉络宁静脉用药配合调强适形放射治疗鼻咽癌的疗效和毒副反应。方法36例鼻咽癌患者随机分为研究组和对照组，各18例，所有病例均采用调强适形放疗。研究组18例同时连续28日每日一次静脉应用脉络宁注射液20 ml。对两组患者的放射治疗的临床疗效及放疗毒副反应进行比较分析。结果研究组1年、3年总生存率较对照组无显著性差异，（P>0.05）；研究组Ⅲ级放射性口腔粘膜炎、放射性皮肤反应、颈部活动受限发生率均较对照组低，有显著性差异（P<0.05）。结论脉络宁静脉用药配合调强适形放疗鼻咽癌可以有效减轻放疗中、放疗后患者的毒副反应，提高患者的生活质量。
목적：탐토맥락저정맥용약배합조강괄형방사치료비인암적료효화독부반응。방법36례비인암환자수궤분위연구조화대조조，각18례，소유병례균채용조강괄형방료。연구조18례동시련속28일매일일차정맥응용맥락저주사액20 ml。대량조환자적방사치료적림상료효급방료독부반응진행비교분석。결과연구조1년、3년총생존솔교대조조무현저성차이，（P>0.05）；연구조Ⅲ급방사성구강점막염、방사성피부반응、경부활동수한발생솔균교대조조저，유현저성차이（P<0.05）。결론맥락저정맥용약배합조강괄형방료비인암가이유효감경방료중、방료후환자적독부반응，제고환자적생활질량。
Objective To evaluate the clinical effect and toxicity of intensity modulated radiation therapy(IMRT)combined with mailuoning injection in treatment of nasopharyngeal carcinoma. Methods 36 patients with nasopharyngeal carcinoma were randomly divided into research group and the control group,all 18 cases,all cases using intensity modulated conformal radiotherapy.Team of 18 patients and 28 consecutive once-daily intravenous application context ning injection 20 ml.On two groups of patients with the clinical curative effect of radiotherapy and radiotherapy toxicity comparison analysis. Results There was no significant difference of 1 year、3 year survival rate in two groups (P>0.05). But The rate of radiotherapy-induced mucositis and radiation-induced dermal injury in experimental group were lower than control group (P<0.05). Conclusion Concurrent mailuoning injection and IMRT in nasopharyngeal cancer can ease the toxicity induced by radiotherapy.Improving the quality of life.