CAJ | 학술논문

目的：优化埃索美拉唑镁生产工艺，在埃索美拉唑钠成熟工艺的基础上，使得埃索美拉唑镁生产工艺简单，收率高，产品质量稳定，解决产品含量低，收率不高的问题。方法埃索美拉唑钠在15N的纯化水中溶解，滴加0．5～0．6N的氯化镁水溶液，反应5h经过后处理得到产品埃索美拉唑镁。结果得到白色埃索美拉唑镁，摩尔收率85％，质量符合产品质量标准。结论该工艺操作简单，产品质量和收率符合车间生产要求。
목적：우화애색미랍서미생산공예，재애색미랍서납성숙공예적기출상，사득애색미랍서미생산공예간단，수솔고，산품질량은정，해결산품함량저，수솔불고적문제。방법애색미랍서납재15N적순화수중용해，적가0．5～0．6N적록화미수용액，반응5h경과후처리득도산품애색미랍서미。결과득도백색애색미랍서미，마이수솔85％，질량부합산품질량표준。결론해공예조작간단，산품질량화수솔부합차간생산요구。
ABSTRACT:OBJECTIVE To optimize Esomeprazole magnesium production process .On the basis of Esome-prazole sodium mature process , make Esomeprazole magnesium production process is simple , high yield, quality of products more stable ,and solve the problem of low product content and low yield .METHODS Esomeprazole sodi-um dissolved in purified water 15N, dropping 0.5 ~0.6N aqueous solution of magnesium chloride ,5h reaction product obtained after treatment with Esomeprazole magnesium .RESULTS White Esomeprazole magnesium was Get,molar yield was 85%,product quality in line with quality standards .CONCLUSION The process is simple operation,product quality and yield in line with the requirements of plant production.