CAJ | 학술논문

目的：：探讨度洛西汀治疗广泛性焦虑的疗效与安全性。方法：随机将86例广泛性焦虑患者分为度洛西汀组44例和帕罗西汀组42例，观察6周，在治疗前和治疗每周末用汉密尔顿焦虑量表( HAMA)、临床疗效总体评定量表( CGI)评定两组患者的疗效，用副反应量表(TESS)评定患者的不良反应。结果：度洛西汀组患者总有效率为90.9%；帕罗西汀组患者总有效率为88.1%，两组患者疗效差异无统计学意义(P>0.05)，两组患者在治疗6周末HAMA评分低于治疗前，差异有显著性(P<0.01)；度洛西汀组患者起效快；两组患者不良反应无统计学意义(P>0.05)。结论：度洛西汀与帕罗西汀治疗广泛性焦虑均有效，但度洛西汀较帕罗西汀起效快，不良反应轻微。
목적：：탐토도락서정치료엄범성초필적료효여안전성。방법：수궤장86례엄범성초필환자분위도락서정조44례화파라서정조42례，관찰6주，재치료전화치료매주말용한밀이돈초필량표( HAMA)、림상료효총체평정량표( CGI)평정량조환자적료효，용부반응량표(TESS)평정환자적불량반응。결과：도락서정조환자총유효솔위90.9%；파라서정조환자총유효솔위88.1%，량조환자료효차이무통계학의의(P>0.05)，량조환자재치료6주말HAMA평분저우치료전，차이유현저성(P<0.01)；도락서정조환자기효쾌；량조환자불량반응무통계학의의(P>0.05)。결론：도락서정여파라서정치료엄범성초필균유효，단도락서정교파라서정기효쾌，불량반응경미。
Objective:To explore effects and safety of Duloxetine in treatment of generalized anxiety disorder ( GAD) . Meth-ods:86 patients with GAD were randomly divided into study group (Duloxetine group, n=44) and control group (Paroxetine group, n=44) and observed for 6 weeks. Both groups were tested with Hamilton anxiety scale (HAMA), clinical global impression (CGI) and treatment emergent symptom scale (TESS) before the treatment and 1, 2, 4, 6 weeks after the treatment for effects and adverse reac-tions. Results:The total effective rates of Duloxetine group and Paroxetine group were 90. 9% and 88. 1%, and the difference was not statistically significant (P>0. 05). The HAMA scores of the two groups 6 weeks after the treatment were lower than those before the treatment, and the differences were statistically significant (P<0. 01). Duloxetine had a quicker effect. There was no statistical differ-ence in adverse reactions between the two groups (P>0. 05). Conclusions:Both Duloxetine and Paroxetine are effective in the treat-ment of generalized anxiety patients, however, Duloxetine has an earlier response and less adverse reactions compared with Paroxetine.