CAJ | 학술논문

目的：观察加味玉屏风散及单味中药对假丝酵母菌的体外抑菌效果，旨在寻求中药在抗真菌方面的优势作用。方法用琼脂稀释法观察加味玉屏风散各组和单味中药黄连、茵陈、炙黄芪对104株假丝酵母菌的体外抑菌作用。结果玉屏风散＋黄连、玉屏风散＋黄连＋茵陈、黄连的抑菌效果较好，50％最低抑菌浓度（MIC50）分别为6．25、25．00、1．56 g· L－1，且对热带假丝酵母菌的抑菌效果最好，其次为光滑假丝酵母菌、白假丝酵母菌和葡萄牙假丝酵母菌，对近平滑假丝酵母菌抑菌效果较差。玉屏风散和炙黄芪仅对热带假丝酵母菌有一定抑菌效果，未发现茵陈对假丝酵母菌有抑菌作用。结论黄连及含黄连的加味玉屏风散对各种假丝酵母菌均有抑制作用，尤其是对耐药率较高的非白假丝酵母菌有较强的抑菌功效。这点对临床研究更有价值。
목적：관찰가미옥병풍산급단미중약대가사효모균적체외억균효과，지재심구중약재항진균방면적우세작용。방법용경지희석법관찰가미옥병풍산각조화단미중약황련、인진、자황기대104주가사효모균적체외억균작용。결과옥병풍산＋황련、옥병풍산＋황련＋인진、황련적억균효과교호，50％최저억균농도（MIC50）분별위6．25、25．00、1．56 g· L－1，차대열대가사효모균적억균효과최호，기차위광활가사효모균、백가사효모균화포도아가사효모균，대근평활가사효모균억균효과교차。옥병풍산화자황기부대열대가사효모균유일정억균효과，미발현인진대가사효모균유억균작용。결론황련급함황련적가미옥병풍산대각충가사효모균균유억제작용，우기시대내약솔교고적비백가사효모균유교강적억균공효。저점대림상연구경유개치。
Objective Through observing the in vitro inhibition effects of flavored yupinfeng powder and single traditional Chinese med-icine against candida, to seek the antifungal effects of traditional Chinese medicine ( TCM) .Methods Using AGAR dilution method to observe in vitro inhibition effect of the flavored yupingfeng powder and single traditional Chinese medicine( e.g., rhizoma coptidis , herba artemisiae, Radix Astragali preparata) to 104 strains of candida.Results Fungi inhibition effects of Yupingfeng powder +rhi-zoma coptidis, yupingfeng powder +rhizoma coptidis +herba artemisiae, and rhizoma coptidis are good.The minimal inhibitory con-centrations of 50%(MIC50) were 6.25, 25.00 and 1.56 g· L-1, respectively.Tropical candida showed best inhibitory response, fol-lowed by smooth-candida, white candida and portugal candida, while nearly smooth candida the worst.Yupingfeng powder and Radix Astragali preparata has certain antifungal effects only for tropical candida.Herba artemisiae didn’ t show any antifungal effects.Con-clusions Rhizoma coptidis and the flavored yupingfeng powder with coptis has strong inhibition efficacy for a variety of candida, espe-cially for the non-Candida albicans with higher percentages.It is more valuable for clinical research.