CAJ | 학술논문

目的：观察0.025％醋酸地塞米松乳膏联合肤乐霜治疗婴幼儿湿疹和特应性皮炎的临床疗效及安全性。方法采用随机对照法，入选患儿分为3组，A组外用0.025%醋酸地塞米松乳膏每日2次，B组外用肤乐霜每日2次，C组外用0.025%醋酸地塞米松乳膏和肤乐霜每日各1次，均共治疗2周。采用SCORAD评分对受试者的病情严重程度进行评估。结果本研究最终入选并完成试验210例，A组69例，B组71例，C组70例；3组患儿性别、年龄、疾病类型及试验前SCORAD评分的差异均无统计学意义。治疗结束时，A组的临床总有效率为83％（57/69），B组为65％（46/71），C组为84%（59/70），3组比较差异有统计学意义（P<0.01）；两两比较，A组和C组的疗效差异无统计学意义，均好于B组。3组均未见药物相关的不良反应。结论0.025％醋酸地塞米松乳膏联合肤乐霜治疗婴幼儿湿疹和特应性皮炎疗效可靠，安全性高。
목적：관찰0.025％작산지새미송유고연합부악상치료영유인습진화특응성피염적림상료효급안전성。방법채용수궤대조법，입선환인분위3조，A조외용0.025%작산지새미송유고매일2차，B조외용부악상매일2차，C조외용0.025%작산지새미송유고화부악상매일각1차，균공치료2주。채용SCORAD평분대수시자적병정엄중정도진행평고。결과본연구최종입선병완성시험210례，A조69례，B조71례，C조70례；3조환인성별、년령、질병류형급시험전SCORAD평분적차이균무통계학의의。치료결속시，A조적림상총유효솔위83％（57/69），B조위65％（46/71），C조위84%（59/70），3조비교차이유통계학의의（P<0.01）；량량비교，A조화C조적료효차이무통계학의의，균호우B조。3조균미견약물상관적불량반응。결론0.025％작산지새미송유고연합부악상치료영유인습진화특응성피염료효가고，안전성고。
Objective To evaluate the efficiacy and safety of 0.025% dexamethasone acetate cream combined with Fuleshuang cream in infantile eczema and atopic dermatitis. Methods A randomized controlled study was conducted. Sixty-nine patients in group A were treated with 0.025% dexamethasone acetate cream twice daily, 71 patients in group B were treated with Fuleshuang cream twice daily, 70 patients in group C were treated with 0.025% dexamethasone acetate cream combine with Fuleshuang cream once daily. All patients were treated for 2 weeks. Eczema severity was evaluated by SCORAD score. Results At the end of this 2 weeks study, the clinical effective rate of group A, B and C was 83%, 65%, 84% respectively, with a significant difference among the three groups (P< 0.01). There was no difference in the clinical effective rate of group A and C, but better than group B. No adverse effect was found related to the drug in the three groups. Conclusion 0.025% dexamethasone acetate cream combined with Fuleshuang cream is effective and safe for in-fantile patients with eczema and atopic dermatitis.