CAJ | 학술논문

目的：探讨γ干扰素释放分析试验在肺结核病中的诊断价值。方法选取2013年5~11月首都医科大学附属北京胸科医院菌阳肺结核患者和菌阴肺结核患者各120例，结核病患者密切接触者、健康志愿者各40例，同时行γ干扰素释放分析试验，以酶联免疫斑点技术法检测结核分枝杆菌感染T细胞（T-SPOT.TB检测），比较各组检出阳性率。结果γ干扰素释放分析试验诊断肺结核病的敏感性为87%（208/240），对结核病患者密切接触者的特异性为55%（22/40），健康志愿者的特异性为100%（40/40）。结论γ干扰素释放分析试验对肺结核病的诊断具有较高的敏感性和特异性。
목적：탐토γ간우소석방분석시험재폐결핵병중적진단개치。방법선취2013년5~11월수도의과대학부속북경흉과의원균양폐결핵환자화균음폐결핵환자각120례，결핵병환자밀절접촉자、건강지원자각40례，동시행γ간우소석방분석시험，이매련면역반점기술법검측결핵분지간균감염T세포（T-SPOT.TB검측），비교각조검출양성솔。결과γ간우소석방분석시험진단폐결핵병적민감성위87%（208/240），대결핵병환자밀절접촉자적특이성위55%（22/40），건강지원자적특이성위100%（40/40）。결론γ간우소석방분석시험대폐결핵병적진단구유교고적민감성화특이성。
Objective To investigate the diagnostic value of interferon-γ release assay in pulmonary tuberculosis patients. Methods One hundred and twenty cases of sputum positive pulmonary tuberculosis patients and 120 smear-negative pulmonary tuberculosis patients, 40 close contacts of patients with tuberculosis and 40 cases of healthy volunteers in May-November 2013 in Beijing Chest Hospital were included into this study. An ELISPOT-based interfer-on-γrelease assay (T-SPOT.TB) was tested at the same time. SPSS 17.0 statistical software was used for statistical analy-sis. Chi-square test and paired Chi-square test were used to detect the positive rate. Results The sensitivity of interfer-on-γ release assay in pulmonary tuberculosis patients was 87%(208/240), the specificity of close contacts of patients with tuberculosis was 55% (22/40), the specificity was 100% (40/40) for healthy volunteers. Conclusion Interferon-γ release assay has high sensitivity and specificity for the diagnosis of pulmonary tuberculosis.