河北医科大学学报
河北醫科大學學報
하북의과대학학보
JOURNAL OF HEBEI MEDICAL UNIVERSITY
2015年
2期
173-176
,共4页
脑膜炎%细菌感染%抗药性
腦膜炎%細菌感染%抗藥性
뇌막염%세균감염%항약성
meningitis%bacterial infection%drug resistance
目的：探讨新生儿化脓性脑膜炎脑脊液病原菌分布、抗生素敏感和耐药情况，为临床诊治提供实验室依据。方法对临床诊断的28例化脓性脑膜炎患儿脑脊液细菌培养和耐药性以及敏感性进行分析。结果28例化脓性脑膜炎患儿脑脊液病原菌分布：单菌株27例，双菌株1例。其中革兰阴性菌20株（68．96％），革兰阳性菌8株（27．59％），白色念珠菌1株（3．45％）。革兰阴性菌对氨苄西林、复方新诺明、哌拉西林的耐药率达80．00％以上，对头孢唑林、四环素、头孢噻肟的耐药率在60．00％以上。共检出产超广谱β-内酰胺酶菌8株，未检出对美罗培南耐药的革兰阴性菌。革兰阳性菌大部分对氨苄西林、复方新诺明、头孢西丁、红霉素耐药，未检出对万古霉素耐药的革兰阳性菌。结论新生儿化脓性脑膜炎脑脊液病原菌以革兰阴性菌为主，对多种抗生素耐药。
目的：探討新生兒化膿性腦膜炎腦脊液病原菌分佈、抗生素敏感和耐藥情況，為臨床診治提供實驗室依據。方法對臨床診斷的28例化膿性腦膜炎患兒腦脊液細菌培養和耐藥性以及敏感性進行分析。結果28例化膿性腦膜炎患兒腦脊液病原菌分佈：單菌株27例，雙菌株1例。其中革蘭陰性菌20株（68．96％），革蘭暘性菌8株（27．59％），白色唸珠菌1株（3．45％）。革蘭陰性菌對氨芐西林、複方新諾明、哌拉西林的耐藥率達80．00％以上，對頭孢唑林、四環素、頭孢噻肟的耐藥率在60．00％以上。共檢齣產超廣譜β-內酰胺酶菌8株，未檢齣對美囉培南耐藥的革蘭陰性菌。革蘭暘性菌大部分對氨芐西林、複方新諾明、頭孢西丁、紅黴素耐藥，未檢齣對萬古黴素耐藥的革蘭暘性菌。結論新生兒化膿性腦膜炎腦脊液病原菌以革蘭陰性菌為主，對多種抗生素耐藥。
목적：탐토신생인화농성뇌막염뇌척액병원균분포、항생소민감화내약정황，위림상진치제공실험실의거。방법대림상진단적28례화농성뇌막염환인뇌척액세균배양화내약성이급민감성진행분석。결과28례화농성뇌막염환인뇌척액병원균분포：단균주27례，쌍균주1례。기중혁란음성균20주（68．96％），혁란양성균8주（27．59％），백색념주균1주（3．45％）。혁란음성균대안변서림、복방신낙명、고랍서림적내약솔체80．00％이상，대두포서림、사배소、두포새우적내약솔재60．00％이상。공검출산초엄보β-내선알매균8주，미검출대미라배남내약적혁란음성균。혁란양성균대부분대안변서림、복방신낙명、두포서정、홍매소내약，미검출대만고매소내약적혁란양성균。결론신생인화농성뇌막염뇌척액병원균이혁란음성균위주，대다충항생소내약。
Objective To investigate the bacteria distribution of neonatal purulent meningitis,antibiotic sensitivity and resistance,and provide laboratory evidence for clinical diagnosis and treatment.Methods Twenty-eight cases diagnosed purulent meningitis were recruited into this study.The bacterial culture,drug resistance and sensitivity of cerebrospinal fluid from the patients were analyzed.Results The pathogen distribution in the cerebrospinal fluid of 28 cases with neonatal purulent meningitis:27 cases with cultured single strain,just 1 case with two strains.In this findings,there were 20 gram-negative bacteria strains (68.96%),8 gram-positive bacteria strains (27.59%),1 candida albicans strain (3.45%).The drug resistant rate of gram-negative bacteria to ampicillin,cotrimoxazole,piperacillin was more than 80.00%;on the other hand,it was up to 60.00% to cefazolin,tetracycline,cefotaxime.Eight strains of extended spectrum beta lactamase bacteria were tested in this study.Gram-negative bacteria resistant to meropenem and amikacin were not detected.Most gram-positive bacteria showed drug resistance to ampicillin,cotrimoxazole,erythromycin,cefoxitin.There was none detected in gram-positive bacteria resistant to vancomycin.Conclusion Gram-negative bacteria was the major pathogens in neonatal purulent meningitis,and they were resistant to multiple antibiotics.
