光谱学与光谱分析
光譜學與光譜分析
광보학여광보분석
SPECTROSCOPY AND SPECTRAL ANALYSIS
2015年
2期
552-556
,共5页
功能近红外光谱%氧合血红蛋白%脱氧血红蛋白%脑功能激活%频分复用
功能近紅外光譜%氧閤血紅蛋白%脫氧血紅蛋白%腦功能激活%頻分複用
공능근홍외광보%양합혈홍단백%탈양혈홍단백%뇌공능격활%빈분복용
Functional near-infrared spectroscopy%Oxygenated hemoglobin%Deoxygenated hemoglobin%Functional brain activa-tion%Frequency multiplexing
功能近红外光谱（functional near-infrared spectroscopy，fNIRS）是一种无损的脑成像技术，经过20年的发展，已广泛应用于认知神经科学研究领域。基于神经血管耦合机制，与功能相关的大脑神经活动增强会引起局部脑血流量的升高，进而引发血液中氧合血红蛋白与脱氧血红蛋白浓度相应的变化，间接反映了大脑中神经激活程度。研制了一套基于多功能采集卡的单通道连续波fNIRS系统。在该系统中，选择激光二极管作为光源具有较好的单色性和较低的发散角，690和830 nm 波长的组合有助于降低发色团之间的串扰。频分复用技术用于区分来自不同光源的信号，同时也消除了环境光、工频干扰等特定频率的噪声源。利用LabVIEW软件平台实现了光源的时序控制、自动增益调节、数字正交相干解调，以及数据可视化与存储等功能。屏气和心算实验结果表明，该系统可用于监测大脑局部血红蛋白浓度的实时变化，并可以检测与高级脑功能相关的激活。
功能近紅外光譜（functional near-infrared spectroscopy，fNIRS）是一種無損的腦成像技術，經過20年的髮展，已廣汎應用于認知神經科學研究領域。基于神經血管耦閤機製，與功能相關的大腦神經活動增彊會引起跼部腦血流量的升高，進而引髮血液中氧閤血紅蛋白與脫氧血紅蛋白濃度相應的變化，間接反映瞭大腦中神經激活程度。研製瞭一套基于多功能採集卡的單通道連續波fNIRS繫統。在該繫統中，選擇激光二極管作為光源具有較好的單色性和較低的髮散角，690和830 nm 波長的組閤有助于降低髮色糰之間的串擾。頻分複用技術用于區分來自不同光源的信號，同時也消除瞭環境光、工頻榦擾等特定頻率的譟聲源。利用LabVIEW軟件平檯實現瞭光源的時序控製、自動增益調節、數字正交相榦解調，以及數據可視化與存儲等功能。屏氣和心算實驗結果錶明，該繫統可用于鑑測大腦跼部血紅蛋白濃度的實時變化，併可以檢測與高級腦功能相關的激活。
공능근홍외광보（functional near-infrared spectroscopy，fNIRS）시일충무손적뇌성상기술，경과20년적발전，이엄범응용우인지신경과학연구영역。기우신경혈관우합궤제，여공능상관적대뇌신경활동증강회인기국부뇌혈류량적승고，진이인발혈액중양합혈홍단백여탈양혈홍단백농도상응적변화，간접반영료대뇌중신경격활정도。연제료일투기우다공능채집잡적단통도련속파fNIRS계통。재해계통중，선택격광이겁관작위광원구유교호적단색성화교저적발산각，690화830 nm 파장적조합유조우강저발색단지간적천우。빈분복용기술용우구분래자불동광원적신호，동시야소제료배경광、공빈간우등특정빈솔적조성원。이용LabVIEW연건평태실현료광원적시서공제、자동증익조절、수자정교상간해조，이급수거가시화여존저등공능。병기화심산실험결과표명，해계통가용우감측대뇌국부혈홍단백농도적실시변화，병가이검측여고급뇌공능상관적격활。
With the development in last twenty years,functional near-infrared spectroscopy (fNIRS)is a non-invasive brain ima-ging technique which widely used in cognitive neuroscience studies.Based on mechanism of neurovascular coupling,increased functional neural activities in brain induce higher regional cerebral blood flow,which will cause relative concentration change of oxygenated and deoxygenated hemoglobin.In this paper,a single channel continuous wave fNIRS system based on multi-function data acquisition board was proposed.With the benefits of narrow spectral peaks and low divergence,laser diodes provided a bet-ter accuracy for measurement with optimal dual-wavelength of 690 and 830 nm.Frequency multiplexing technique was used to distinguish light sources from different emitters,and remove environmental stable interference sources such as ambient light and line power noise as well.LabVIEW was used to design graphical user interface with functionalities including source sequence schedule,auto gain setting,digital in-phase and quadrature demodulation,data visualization and storage.The experimental re-sults during holding breath and mental arithmetic task indicated that our system was capable of monitoring regional concentration change of hemoglobin in real time,and detecting activation associated with advanced brain functions.
