CAJ | 학술논문

目的：分析研究新辅助化疗联合手术治疗局部晚期食管癌的临床疗效。方法将52例ⅡA～Ⅲ期食管癌患者随机分为观察组30例和对照组22例。观察组给予依托泊苷（VP16）联合5-氟尿嘧啶（5-FU）、顺铂（DDP）治疗，化疗结束后4周行食管癌根治术。对照组患者仅给予单纯手术治疗。结果观察组6个月和1年生存率分别为93.33%、83.33%，对照组术后6个月和1年的生存率分别为81.82%、72.73%，两组间比较，差异有统计学意义（P＜0.05）；两组患者术前生存质量评分比较，差异无统计学意义（P＞0.05），治疗后6个月、1年后观察组生存质量评分高于对照组（P＜0.05）。结论新辅助化疗联合手术治疗局部晚期食管癌可以显著提高患者近期生存率、改善预后，值得推广应用。
목적：분석연구신보조화료연합수술치료국부만기식관암적림상료효。방법장52례ⅡA～Ⅲ기식관암환자수궤분위관찰조30례화대조조22례。관찰조급여의탁박감（VP16）연합5-불뇨밀정（5-FU）、순박（DDP）치료，화료결속후4주행식관암근치술。대조조환자부급여단순수술치료。결과관찰조6개월화1년생존솔분별위93.33%、83.33%，대조조술후6개월화1년적생존솔분별위81.82%、72.73%，량조간비교，차이유통계학의의（P＜0.05）；량조환자술전생존질량평분비교，차이무통계학의의（P＞0.05），치료후6개월、1년후관찰조생존질량평분고우대조조（P＜0.05）。결론신보조화료연합수술치료국부만기식관암가이현저제고환자근기생존솔、개선예후，치득추엄응용。
Objective Clinical therapeutic effect in the treatment of locally advanced esophageal carcinoma: analysis of neoadjuvant chemotherapy on the jointoperation. Methods 52 cases of esophageal cancer patients with stage III and II A~were randomly divided into the observation group 30 cases and control group with 22 cases. The observation group was given etoposide (VP16) combined with 5-lfuorouracil (5-FU) and cisplatin (DDP) chemotherapy treatment, at 4 weeks afterradical operation of carcinoma of esophagus. The control group were only givensimple surgical treatment. Results In the observation group, 6 months and 1 year survival rates were 93.33%, 83.33%, the control group after 6 months and 1 yearsurvival rates were 81.82%, 72.73%, two the differences between groups was statistically signiifcant (P<0.05); two patients were survival quality score group before compare difference not to have statistical signiifcance (P>0.05), after 6 months of treatment, 1 years after the observation group quality of life scoreshigher than the control group (P<0.05). Conclusion Can signiifcantly improve theshort-term survival rate and improve the prognosis in patients with neoadjuvantchemotherapy combined with surgery in the treatment of locally advancedesophageal carcinoma, and is worthy of popularization and application.