CAJ | 학술논문

目的：探讨吸入5%二氧化碳混合气体BOLD-MRI与前列腺增生(BPH)和前列腺癌(PCa)中微血管特征的对应关系。方法采用美国 GE Signa Excite HD 3.0T超导型磁共振成像仪和腹部相控阵线圈,在吸入5%二氧化碳混合气体行 BOLD-MRI。画取正常前列腺外周带(PZ)、中央腺区(CZ)、BPH 和PCa感兴趣区(ROI),记录时间-信号强度曲线(TIC)和信号强度平均增加率。免疫组化分析BPH 和PCa微血管形态学特征：平均直径、平均面积、平均周长及异型指数。结果 CZ、PZ、BPH 及 PCa 区信号强度于吸入混合气体后高于吸入混合气体前(P<0.05)；吸入混合气体后正常 CZ、PZ、BPH 及 PCa 区的相对平均信号强度增加率分别为(5.07±1.08)%、(2.78±1.13)%、(6.44±2.02)%和(1.77±0.40)%,BPH 和PCa组织中的 MVD数分别为12.32±3.14和30.22±11.19(P<0.01)；PCa血管的平均直径、平均面积、平均周长及异型指数均小于 BPH 的相应指标(P<0.01)。结论前列腺疾病吸入混合气体BOLD-MRI表现与组织的微血管特征有关,有助于评价组织微血管结构功能状态。
목적：탐토흡입5%이양화탄혼합기체BOLD-MRI여전렬선증생(BPH)화전렬선암(PCa)중미혈관특정적대응관계。방법채용미국 GE Signa Excite HD 3.0T초도형자공진성상의화복부상공진선권,재흡입5%이양화탄혼합기체행 BOLD-MRI。화취정상전렬선외주대(PZ)、중앙선구(CZ)、BPH 화PCa감흥취구(ROI),기록시간-신호강도곡선(TIC)화신호강도평균증가솔。면역조화분석BPH 화PCa미혈관형태학특정：평균직경、평균면적、평균주장급이형지수。결과 CZ、PZ、BPH 급 PCa 구신호강도우흡입혼합기체후고우흡입혼합기체전(P<0.05)；흡입혼합기체후정상 CZ、PZ、BPH 급 PCa 구적상대평균신호강도증가솔분별위(5.07±1.08)%、(2.78±1.13)%、(6.44±2.02)%화(1.77±0.40)%,BPH 화PCa조직중적 MVD수분별위12.32±3.14화30.22±11.19(P<0.01)；PCa혈관적평균직경、평균면적、평균주장급이형지수균소우 BPH 적상응지표(P<0.01)。결론전렬선질병흡입혼합기체BOLD-MRI표현여조직적미혈관특정유관,유조우평개조직미혈관결구공능상태。
Objective To investigate the relationship between micro-vascular features and carbogen breathing BOLD-MRI in be-nign prostatic hyperplasia (BPH)and prostate cancer (PCa).Methods Carbogen breathing BOLD-fMRI was performed using a 3.0 Tesla superconducting magnetic scanner (GE)equipped with a phased-array multi-coil.The regions of interest (ROI)of central zone (CZ),peripheral zone (PZ),BPH and PCa were drawn.The relative increase signal rates and time signal intensity curve (TIC) were recorded.The average diameter,area,circumference and special shape index of micro-vascular were analyzed using immunohis-tochemical stain.The relationship between micro-vascular features and BOLD-MRI was analyzed using SPSS 1 1 .5 .Results The sig-nal intensities of CZ,PZ,BPH and PCa during carbogen breathing were higher than those during air breathing (P<0.05).The rela-tive increasing rate of TIC of CZ,PZ,BPH and PCa after carbogen breathing were (5.07±1.08)%,(2.78±1.13)%,(6.44± 2.02)% and (1.77±0.40)% (P<0.05).The mean MVD of BPH and PCa were 12.32±3.14/field and 30.22±11.19/field (P<0.05).The average diameter,area,circumference and special-shape index of PCa were lower than those of BPH (P<0.05).Conclu-sion Carbogen inhaling BOLD-MRI is related with the micro-vascular structures in BPH and PCa,which will have potential to eval-uate the function and maturity of micro-vascular.