CAJ | 학술논문

目的：探讨肝癌患者动脉灌注化疗栓塞(TACE)后肝功能严重失代偿的相关因素。方法回顾性分析接受 TACE治疗的109例患者，单因素分析性别、年龄、外科切除史、肝硬化史、肿瘤大体分型、TACE 次数、动门静脉瘘、门脉癌栓、Child-Pugh 分级、血清总胆红素、白蛋白、天门冬氨酸氨基转移酶、吲哚菁绿15 min 滞留率和术中碘油用量与术后发生严重肝功能失代偿的相关性，并将有统计学意义(P <0.05)的结果引入 Logistic 回归模型分析。结果肝硬化、Child-Pugh 分级、门脉癌栓、白蛋白和吲哚菁绿15 min 滞留率与术后发生严重的肝功能失代偿相关，多项 Logistic 回归分析显示：肝硬化、门脉癌栓和吲哚菁绿15 min 滞留率是导致术后发生严重肝功能失代偿的危险因素。结论导致 TACE 后发生肝功能严重失代偿的危险因素有肝硬化、门脉癌栓和吲哚菁绿15 min 滞留率，需要在术前评估中引起警惕。
목적：탐토간암환자동맥관주화료전새(TACE)후간공능엄중실대상적상관인소。방법회고성분석접수 TACE치료적109례환자，단인소분석성별、년령、외과절제사、간경화사、종류대체분형、TACE 차수、동문정맥루、문맥암전、Child-Pugh 분급、혈청총담홍소、백단백、천문동안산안기전이매、신타정록15 min 체류솔화술중전유용량여술후발생엄중간공능실대상적상관성，병장유통계학의의(P <0.05)적결과인입 Logistic 회귀모형분석。결과간경화、Child-Pugh 분급、문맥암전、백단백화신타정록15 min 체류솔여술후발생엄중적간공능실대상상관，다항 Logistic 회귀분석현시：간경화、문맥암전화신타정록15 min 체류솔시도치술후발생엄중간공능실대상적위험인소。결론도치 TACE 후발생간공능엄중실대상적위험인소유간경화、문맥암전화신타정록15 min 체류솔，수요재술전평고중인기경척。
Objective To investigate the relative risk factors of severe hepatic dysfunction after transcatheter arterial chemoembo-lization (TACE)in patients with liver cancer.Methods 109 cases with liver cancer after TACE treatment were retrospectively re-viewed.,The factors related to severe hepatic dysfunction after TACE including sex,age,surgical resection history,cirrhosis of the liver,tumor type,number of TACE,arterioportal shunting,portal vein thrombosis,Child-pugh grade,TBIL,level of ALB,AST, ICGR1 5 and the volume of lipiodol injected were ananlyzed by univariate analysis.Then the significant factors were taken into the multivariate logistic regression analysis.Results There was a postive relationship between cirrhosis of the liver,portal vein throm-bosis,level of ALB and ICGR1 5 and severe hepatic dysfunction after TACE (P <0.05 ).Furthermore,cirrhosis of the liver,portal vein thrombosis and ICGR1 5 were the risk factors for severe hepatic dysfunction after TACE.Conclusion The relative risk factors of severe hepatic dysfunction after TACE including cirrhosis of the liver,portal vein thrombosis and ICGR1 5,which should to be noted in the preoperative assessment.