实用医药杂志
實用醫藥雜誌
실용의약잡지
Practical Journal of Medicine & Pharmacy
2015年
2期
124-126
,共3页
核苷(酸)类似物%乙肝病毒相关肝细胞癌%预防%治疗
覈苷(痠)類似物%乙肝病毒相關肝細胞癌%預防%治療
핵감(산)유사물%을간병독상관간세포암%예방%치료
Nucleoside analogues(NAs)%HBV-related hepatocellular carcinoma%Prevention%Treatment
肝细胞肝癌(HCC)是预后极差的肿瘤,在我国慢性乙肝病毒(HBV)感染是诱发HCC的最危险的因素;通常抗病毒治疗是慢性HBV感染的基本疗法,其中核苷(酸)类似物(NAs),包括拉夫米定、阿德福韦酯、替比夫定和恩替卡韦等,都已广泛用于抗HBV感染;在治疗HCC的不同方案(如,手术、动脉导管栓塞、射频消融及肝移植等)中,应用NAs能防止HBV活化,改善肝功能,减少HCC复发。
肝細胞肝癌(HCC)是預後極差的腫瘤,在我國慢性乙肝病毒(HBV)感染是誘髮HCC的最危險的因素;通常抗病毒治療是慢性HBV感染的基本療法,其中覈苷(痠)類似物(NAs),包括拉伕米定、阿德福韋酯、替比伕定和恩替卡韋等,都已廣汎用于抗HBV感染;在治療HCC的不同方案(如,手術、動脈導管栓塞、射頻消融及肝移植等)中,應用NAs能防止HBV活化,改善肝功能,減少HCC複髮。
간세포간암(HCC)시예후겁차적종류,재아국만성을간병독(HBV)감염시유발HCC적최위험적인소;통상항병독치료시만성HBV감염적기본요법,기중핵감(산)유사물(NAs),포괄랍부미정、아덕복위지、체비부정화은체잡위등,도이엄범용우항HBV감염;재치료HCC적불동방안(여,수술、동맥도관전새、사빈소융급간이식등)중,응용NAs능방지HBV활화,개선간공능,감소HCC복발。
Hepatocellular carcinoma (HCC) is one of the tumors with worst prognosis. Chronic hepatitis B virus (HBV) infection is the highest risk factor inducing HCC in China. Currently,antiviral therapy is the basic strategies of chronic HBV infection. Nucleoside analogues (NAs),including lamivudine,adefovir,entecavir,and telbivudine,are widely used to against HBV. In the different strategies of HCC treatment,including surgery operation,transcatheter arterial chemoembolization(TACE),radiofrequency ablation,liver transplantation,application of NAs can prevent HBV activation,improve liver function, and reduce HCC recurrence.