CAJ | 학술논문

目的：探讨患者腰身指数（waist－to－height ratio，WHtR）与冠心病危险因素的关系，为冠心病的预防及治疗提供依据和研究材料。方法收集650例拟诊为冠心病且行冠状动脉造影患者作为研究对象，入院2 d内，测量腰围、身高及体重，计算其WHtR及体质量指数（Body Mass Index，BMI），同时取空腹血检测血糖（glucose， GLU）、血脂、尿酸（uric acid，UA）等生化指标，并且收集患者相关临床资料。分析WHtR与冠心病危险因素的关系。结果 WHtR≤0．5的患者与WHtR＞0．5的患者比较，总胆固醇（total cholesterol，TC）、低密度脂蛋白胆固醇（low density lipoprotein cholesterol，LDL－C）、高密度脂蛋白胆固醇（high density lipoprotein cholesterol，HDL－C）、GLU、UA均有显著性差异（P＜0．01）；WHtR与各生化指标的相关性高于BMI；将是否患冠心病作为因变量，以单因素分析筛选出P＜0．05的变量为自变量，进行二分类Logistic逐步回归分析。结论结果显示年龄、WHtR、糖尿病史、高血压史、LDL－C、UA与冠心病呈正相关，而HDL－C与冠心病呈负相关。 WHtR与冠心病危险因素有明显的相关性，可作为预测和评价冠心病风险的一个重要指标。
목적：탐토환자요신지수（waist－to－height ratio，WHtR）여관심병위험인소적관계，위관심병적예방급치료제공의거화연구재료。방법수집650례의진위관심병차행관상동맥조영환자작위연구대상，입원2 d내，측량요위、신고급체중，계산기WHtR급체질량지수（Body Mass Index，BMI），동시취공복혈검측혈당（glucose， GLU）、혈지、뇨산（uric acid，UA）등생화지표，병차수집환자상관림상자료。분석WHtR여관심병위험인소적관계。결과 WHtR≤0．5적환자여WHtR＞0．5적환자비교，총담고순（total cholesterol，TC）、저밀도지단백담고순（low density lipoprotein cholesterol，LDL－C）、고밀도지단백담고순（high density lipoprotein cholesterol，HDL－C）、GLU、UA균유현저성차이（P＜0．01）；WHtR여각생화지표적상관성고우BMI；장시부환관심병작위인변량，이단인소분석사선출P＜0．05적변량위자변량，진행이분류Logistic축보회귀분석。결론결과현시년령、WHtR、당뇨병사、고혈압사、LDL－C、UA여관심병정정상관，이HDL－C여관심병정부상관。 WHtR여관심병위험인소유명현적상관성，가작위예측화평개관심병풍험적일개중요지표。
Objective To investigate the relationship between waist-to-height ratio(WHtR) and risk factors for coronary heart disease for providing evidence and important information for the prevention and treatment of coronary heart disease. Methods A total of 650 patients who were preliminarily diagnosed as coronary heart disease and underwent coronary angiography were enrolled and chosen as study subjects in the present study. Body surveying index containing the patients' waist circumference,height and weight was measured,and WHtR and Body Mass Index(BMI) were computed. At the same time,all patients' preprandial blood was examined for related blood biochemistry index including glucose (GLU),serum lipid and uric acid (UA),and their related clinical characteristic was collected within two days after admission. The relationship between WHtR and risk factors for coronary heart disease was then analyzed. Results There were significant differences in total cholesterol(TC),low density lipoprotein cholesterol(LDL-C),high density lipoprotein cholesterol(HDL-C),GLU and UA between patients with WHtR≤0.5 and those with WHtR>0.5 (P<0.01). WHtR had significantly stronger correlation with related blood biochemistry index than BMI. Whether the patients suffering from coronary heart disease or not was taken as dependent variable and the variables with P<0.05 screened by single factor analysis were taken as independent variable. Binary Logistic stepwise regression analysis was conducted. Conclusion Age,WHtR,diabetes history, hypertension history,LDL-C and UA were positively correlated with coronary heart disease,while HDL-C was negatively correlated with coronary heart disease. WHtR is significantly related to risk factors for coronary heart disease. WHtR could be served as an important index of predicting and evaluating coronary heart disease risks.